Cytokine profile in patients with chronic non-bacterial osteomyelitis, juvenile idiopathic arthritis, and insulin-dependent diabetes mellitus.

Autor: Kostik MM; Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation. Electronic address: kost-mikhail@yandex.ru., Makhova MA; Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation., Maletin AS; Science Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation., Magomedova SM; Republican Children's Clinical Hospital, Makhachkala, Russian Federation; Dagestan State Medical University, Makhachkala, Russian Federation., Sorokina LS; Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation., Tsukasaki M; Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-0033 Tokyo, Japan., Okamoto K; Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-0033 Tokyo, Japan., Takayanagi H; Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-0033 Tokyo, Japan., Vasiliev DS; Sechenov Institute of Evolutionary Physiology and Biochemistry, Saint Petersburg, Russian Federation., Kozlova DI; Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-0033 Tokyo, Japan., Mushkin AY; Science Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2021 Jul; Vol. 143, pp. 155521.
DOI: 10.1016/j.cyto.2021.155521
Abstrakt: Objectives: Our study aimed to evaluate the cytokine levels in pediatric chronic non-bacterial osteomyelitis (CNO) patients and compare these with other immune-mediated diseases and healthy controls.
Methods: In this prospective study, we included 42 children with CNO, 28 patients with non-systemic juvenile idiopathic arthritis (JIA), 17 children with insulin-dependent diabetes mellitus (IDDM), and 30 healthy age-matched controls. In each of the CNO patients and comparison groups, the levels of 14-3-3-η protein, S100A8/A9 protein, interleukin-4 (IL-4), interleukin-17 (IL-17), interleukin-18 (IL-18), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) were measured by ELISA assay.
Results: All studied cytokines in the CNO patients were significantly higher than controls, and IDDM, 14-3-3-η protein, IL-18, IL-4, IL-17, IL-1β, and TNF-α were less than in JIA patients. In the discriminant analysis, ESR, 14-3-3 protein, S100A8/A9, IL-18, IL-4, and TNF-α can discriminate CNO from JIA, and 14-3-3 protein, S100A8/A9, IL-18, IL-17, IL-4, and TNF-α can distinguish CNO from other diseases and HC.
Conclusion: The increased level of pro-inflammatory cytokines confirms the role of monocyte-driven inflammation in CNO patients. Cytokines may prove valuable as biomarkers and potential therapeutic targets for CNO.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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