Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners.

Autor:	Molton JS; Division of Infectious Diseases, National University Hospital, National University Health System, Singapore 119228, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Electronic address: james.molton@wh.org.au., Lee IR; National Centre for Infectious Diseases, Singapore 308442, Singapore., Bertrand D; Genome Institute of Singapore, A⁎STAR, Singapore 138672, Singapore., Ding Y; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore 308433, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore., Kalimuddin S; Department of Infectious Diseases, Singapore General Hospital, Singapore 169608, Singapore., Lye DC; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; National Centre for Infectious Diseases, Singapore 308442, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore 308433, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore., Nagarajan N; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; Genome Institute of Singapore, A⁎STAR, Singapore 138672, Singapore., Gan YH; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore., Archuleta S; Division of Infectious Diseases, National University Hospital, National University Health System, Singapore 119228, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Jun; Vol. 107, pp. 1-4. Date of Electronic Publication: 2021 Apr 16.
DOI:	10.1016/j.ijid.2021.04.012
Abstrakt:	Objectives: Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households. Methods: The clinical K. pneumoniae isolates from a cohort of 24 patients with Klebsiella liver abscess were genotyped, and the stool metagenomes of the index patients and their cohabiting domestic partners were analyzed. Results: K. pneumoniae was identified in 33% of index patient stools, and one index patient's clinical isolate was identified in their domestic partner's stool. Conclusions: This could represent a transmission event or could represent exposure to a common environmental source. (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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