| Autor: |
Taha M; Department of clinical pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Ismail S; Department of clinical pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.; College of clinical pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Imran S; Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia.; Faculty of Applied Science, UiTM Shah Alam, Shah Alam, Selangor, Malaysia., Almandil NB; Department of clinical pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Alomari M; Department of Stem Cell Biology, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Rahim F; Department of Chemistry, Hazara University, Mansehra, Khyber Pakhtunkhwa, Pakistan., Uddin N; Department of Chemistry, University of Karachi, Karachi, Pakistan., Hayat S; Department of Chemistry, Hazara University, Mansehra, Khyber Pakhtunkhwa, Pakistan., Zaman K; Department of Chemistry, Hazara University, Mansehra, Khyber Pakhtunkhwa, Pakistan., Ibrahim M; Department of clinical pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Alghanem B; Medical Research Core Facility and Platforms (MRCFP, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdulaziz Medical City (KAMC), NGHA, Riyadh, Saudi Arabia., Islam I; Medical Research Core Facility and Platforms (MRCFP, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdulaziz Medical City (KAMC), NGHA, Riyadh, Saudi Arabia., Farooq RK; Department of Neuroscience Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Boudjelal M; Medical Research Core Facility and Platforms (MRCFP, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdulaziz Medical City (KAMC), NGHA, Riyadh, Saudi Arabia., Khan KM; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. |
| Abstrakt: |
In search of potent urease inhibitor indole analogues ( 1-22 ) were synthesized and evaluated for their urease inhibitory potential. All analogues ( 1-22 ) showed a variable degree of inhibitory interaction potential having IC 50 value ranging between 0.60 ± 0.05 to 30.90 ± 0.90 µ M when compared with standard thiourea having IC 50 value 21.86 ± 0.90 µ M. Among the synthesized analogues, the compounds 1, 2, 3, 5, 6, 8, 12, 14, 18, 20 and 22 having IC 50 value 3.10 ± 0.10, 1.20 ± 0.10, 4.60 ± 0.10, 0.60 ± 0.05, 5.30 ± 0.20, 2.50 ± 0.10, 7.50 ± 0.20, 3.90 ± 0.10, 3.90 ± 0.10, 2.30 ± 0.05 and 0.90 ± 0.05 µ M respectively were found many fold better than the standard thiourea. All other analogues showed better urease interaction inhibition. Structure activity relationship (SAR) has been established for all analogues containing different substituents on the phenyl ring. To understand the binding interaction of most active analogues with enzyme active site docking study were performed.Communicated by Ramaswamy H. Sarma. |
