Real-world stress resilience is associated with the responsivity of the locus coeruleus.

Autor: Grueschow M; Zurich Center for Neuroeconomics (ZNE), Department of Economics, University of Zurich, Zurich, Switzerland. marcus.grueschow@econ.uzh.ch., Stenz N; Division of Experimental Psychopathology and Psychotherapy, Dept of Psychology, University of Zurich, Zurich, Switzerland.; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland., Thörn H; Division of Experimental Psychopathology and Psychotherapy, Dept of Psychology, University of Zurich, Zurich, Switzerland.; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.; Division of Clinical Psychology and Psychotherapy, Dept of Psychology, University of Zurich, Zurich, Switzerland., Ehlert U; Division of Clinical Psychology and Psychotherapy, Dept of Psychology, University of Zurich, Zurich, Switzerland., Breckwoldt J; Medical School, Deanery, University of Zurich, Zurich, Switzerland., Brodmann Maeder M; Accident and Emergency Department, Inselspital Bern, Bern, Switzerland., Exadaktylos AK; Accident and Emergency Department, Inselspital Bern, Bern, Switzerland., Bingisser R; Department of Emergency Medicine, University Hospital Basel, Basel, Switzerland., Ruff CC; Zurich Center for Neuroeconomics (ZNE), Department of Economics, University of Zurich, Zurich, Switzerland., Kleim B; Division of Experimental Psychopathology and Psychotherapy, Dept of Psychology, University of Zurich, Zurich, Switzerland. birgit.kleim@uzh.ch.; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland. birgit.kleim@uzh.ch.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 Apr 15; Vol. 12 (1), pp. 2275. Date of Electronic Publication: 2021 Apr 15.
DOI: 10.1038/s41467-021-22509-1
Abstrakt: Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are related to the subsequent change in measures of anxiety and depression in response to prolonged real-life stress. We acquired fMRI and pupillometry data during an emotional-conflict task in medical residents before they underwent stressful emergency-room internships known to be a risk factor for anxiety and depression. The LC-NE conflict response and its functional coupling with the amygdala was associated with stress-related symptom changes in response to the internship. A similar relationship was found for pupil-dilation, a potential marker of LC-NE firing. Our results provide insights into the noradrenergic basis of conflict generation, adaptation and stress resilience.
Databáze: MEDLINE
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