Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1 ".

Autor:	Ray S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Valekunja UK; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Stangherlin A; Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK., Howell SA; Francis Crick Institute, London NW1 1AT, UK., Snijders AP; Francis Crick Institute, London NW1 1AT, UK., Damodaran G; Francis Crick Institute, London NW1 1AT, UK., Reddy AB; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. areddy@cantab.net.; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jazyk:	angličtina
Zdroj:	Science (New York, N.Y.) [Science] 2021 Apr 16; Vol. 372 (6539).
DOI:	10.1126/science.abf1941
Abstrakt:	Abruzzi et al argue that transcriptome oscillations found in our study in the absence of Bmal1 are of low amplitude, statistical significance, and consistency. However, their conclusions rely solely on a different statistical algorithm than we used. We provide statistical measures and additional analyses showing that our original analyses and observations are accurate. Further, we highlight independent lines of evidence indicating Bmal1 -independent 24-hour molecular oscillations. (Copyright © 2021, American Association for the Advancement of Science.)
Databáze:	MEDLINE
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