The differential calibration of the HPA axis as a function of trauma versus adversity: A systematic review and p-curve meta-analyses.

Autor: Hosseini-Kamkar N; Cognitive Development and Neuroimaging Laboratory, The Brain and Mind Institute, Western University, London, ON, Canada. Electronic address: nhossei@uwo.ca., Lowe C; Cognitive Development and Neuroimaging Laboratory, The Brain and Mind Institute, Western University, London, ON, Canada. Electronic address: clowe3@uwo.ca., Morton JB; Cognitive Development and Neuroimaging Laboratory, The Brain and Mind Institute, Western University, London, ON, Canada. Electronic address: bmorton3@uwo.ca.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2021 Aug; Vol. 127, pp. 54-135. Date of Electronic Publication: 2021 Apr 20.
DOI: 10.1016/j.neubiorev.2021.04.006
Abstrakt: Although there is an abundance of evidence linking the function of the hypothalamic-pituitary-adrenal (HPA) axis to adverse early-life experiences, the precise nature of the association remains unclear. Some evidence suggests early-life adversity leads to cortisol hyper-reactivity, while other evidence suggests adversity leads to cortisol hypo-reactivity. Here, we distinguish between trauma and adversity, and use p-curves to interrogate the conflicting literature. In Study 1, trauma was operationalized according to DSM-5 criteria; the p-curve analysis included 68 articles and revealed that the literature reporting associations between trauma and blunted cortisol reactivity contains evidential value. Study 2 examined the relationship between adversity and cortisol reactivity. Thirty articles were included in the analysis, and p-curve demonstrated that adversity is related to heightened cortisol reactivity. These results support an inverted U-shaped function relating severity of adversity and cortisol reactivity, and underscore the importance of distinguishing between "trauma" and "adversity".
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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