α,β-Unsaturated γ-Peptide Foldamers.
| Autor: | Legrand B; Institut des Biomolécules Max Mousseron, IBMM, University of Montpellier, ENSCM, CNRS, Montpellier, France., 15 Av. Charles Flahault BP 14 491, 34093, Montpellier Cedex 5, France., Maillard LT; Institut des Biomolécules Max Mousseron, IBMM, University of Montpellier, ENSCM, CNRS, Montpellier, France., 15 Av. Charles Flahault BP 14 491, 34093, Montpellier Cedex 5, France. |
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| Jazyk: | angličtina |
| Zdroj: | ChemPlusChem [Chempluschem] 2021 Apr 01; Vol. 86 (4), pp. 629-645. Date of Electronic Publication: 2021 Apr 01. |
| DOI: | 10.1002/cplu.202100045 |
| Abstrakt: | Despite their concomitant emergence in the 1990s, γ-peptide foldamers have not developed as fast as β-peptide foldamers and to date, only a few γ-oligomer structures have been reported, and with sparse applications. Among these examples, sequences containing α,β-unsaturated γ-amino acids have recently drawn attention since the Z/E configurations of the double bond provide opposite planar restrictions leading to divergent conformational behaviors, from helix to extended structures. In this Review, we give a comprehensive overview of the developments of γ-peptide foldamers containing α,β-unsaturated γ-amino acids with examples of applications for health and catalysis, as well as materials science. (© 2021 Wiley-VCH GmbH.) |
| Databáze: | MEDLINE |
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