Health-related quality of life and pain with selinexor in patients with advanced dedifferentiated liposarcoma.

Autor: Gounder M; Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, NY 10021, USA., Abdul Razak AR; Toronto Sarcoma Program, Princess Margaret Cancer Centre, Toronto, ON, M5G 2C1, Canada., Gilligan AM; Karyopharm Therapeutics, Newton, MA 02459, USA., Leong H; Karyopharm Therapeutics, Newton, MA 02459, USA., Ma X; Karyopharm Therapeutics, Newton, MA 02459, USA., Somaiah N; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Chawla SP; Sarcoma Oncology Center, Santa Monica, CA 90403, USA., Martin-Broto J; Institute of Biomedicine Research (IBIS)/CSIC/Universidad de Sevilla, Virgen del Rocio University Hospital, Calle Antonio Maura Montaner, 41013, Sevilla, Spain., Grignani G; Division of Medical Oncology, Candiolo Cancer Institute, FPO-IRCCS, 10060, Candiolo (TO), Italy., Schuetze SM; Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI 48109, USA., Vincenzi B; Policlinico Universitario Campus, Bio-Medico, Via Álvaro del Portillo, 200, 00128, Roma, Italy., Wagner AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Chmielowski B; Division of Hematology-Oncology, Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90024, USA., Jones RL; The Royal Marsden NHS Foundation Trust & The Institute of Cancer Research, London, SM2 5PT, UK., Shah J; Karyopharm Therapeutics, Newton, MA 02459, USA., Shacham S; Karyopharm Therapeutics, Newton, MA 02459, USA., Kauffman M; Karyopharm Therapeutics, Newton, MA 02459, USA., Riedel RF; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Attia S; Department of Internal Medicine, Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.
Jazyk: angličtina
Zdroj: Future oncology (London, England) [Future Oncol] 2021 Aug; Vol. 17 (22), pp. 2923-2939. Date of Electronic Publication: 2021 Apr 15.
DOI: 10.2217/fon-2021-0284
Abstrakt: Objective: Compare health-related quality of life (HRQoL) of selinexor versus placebo in patients with dedifferentiated liposarcoma. Materials & methods: HRQoL was assessed at baseline and day 1 of each cycle using the European Organization for Research and Treatment of Cancer 30-item core quality of life questionnaire. Results were reported from baseline to day 169 (where exposure to treatment was maximized while maintaining adequate sample size). Results: Pain scores worsened for placebo versus selinexor across all postbaseline visits, although differences in HRQoL at some visits were not significant. Other domains did not exhibit significant differences between arms; however, scores in both arms deteriorated over time. Conclusion: Patients treated with selinexor reported lower rates and slower worsening of pain compared with patients who received placebo.
Databáze: MEDLINE