The effect of subcutaneous injection of methylprednisolone acetate and lidocaine for refractory postherpetic neuralgia: a prospective, observational study.

Autor: Nguyen DT; Department of Neurology Military Hospital 103, Vietnam Military Medical University Hanoi Vietnam., Dang TC; Department of Pathophysiology Vietnam Military Medical University Hanoi Vietnam., Nguyen QA; Stroke Center Phu Tho General Hospital Viet Tri Phu Tho Province Vietnam., Le TD; Department of Neurology Military Hospital 103, Vietnam Military Medical University Hanoi Vietnam., Hoang TD; Department of Neurology Military Hospital 103, Vietnam Military Medical University Hanoi Vietnam., Tran TNT; Department of Neurology Military Hospital 103, Vietnam Military Medical University Hanoi Vietnam., Duong THN; Department of Neurology Military Hospital 103, Vietnam Military Medical University Hanoi Vietnam., Nguyen VT; Department of Rehabilitation Military Hospital 103, Vietnam Military Medical University Hanoi Vietnam., Le VQ; Department of Functional Exploration Military Hospital 103, Vietnam Military Medical University Hanoi Vietnam., Hoang TU; Department of Rehabilitation Military Hospital 103, Vietnam Military Medical University Hanoi Vietnam., Duong MT; Hospital of the 4th Military District Nghe An Vietnam., Nhu DS; Department of Neurology Military Hospital 103, Vietnam Military Medical University Hanoi Vietnam., Phan VN; Department of Neurology Military Hospital 103, Vietnam Military Medical University Hanoi Vietnam.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2021 Apr 08; Vol. 4 (2), pp. e271. Date of Electronic Publication: 2021 Apr 08 (Print Publication: 2021).
DOI: 10.1002/hsr2.271
Abstrakt: Background: Postherpetic neuralgia (PHN) is the most common and bearable complication of herpes zoster (HZ). This pain may have negative impact on the patient's all aspects of daily life and health-related quality of life (HRQOL). Despite numerous advances in treatment, many patients remain resistant to the current therapy options. It is the first time subcutaneous injection of methylprednisolone acetate and lidocaine has been used to treat refractory PHN. We report the results of this treatment evaluating pain relief and HRQOL improvement in this disorder.
Methods: A total of 43 patients with refractory PHN was enrolled in the observational study. All patients received daily subcutaneous injection of methylprednisolone acetate and lidocaine for 10 consecutive days. The severity of pain was assessed by using Visual Analog Scale (VAS), and 36-Item Short Form Survey (SF-36) was applied to evaluate HRQOL. Assessment of the pain and HRQOL was carried out at baseline and posttreatment at 4 weeks as well as 6 and 12 months.
Results: At baseline, all patients experienced severe PHN with average VAS scores of 8.44 ± 0.85 (minimum 7; maximum 10). At 4 weeks, 6 months, and 12 months after treatment, the pain had significantly decreased ( P  < .001), and all subjects showed significant improvement in all eight domains of HRQOL. No major adverse events associated with the subcutaneous injection were observed.
Conclusions: Our results indicate that subcutaneous injection of methylprednisolone acetate and lidocaine can be an effective and safe treatment for PHN.
Competing Interests: The authors declare no potential conflict of interest.
(© 2021 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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