A perspective essay on the use of Ga 3+ as a proxy for Fe 3+ in bioinorganic model studies and its successful use for therapeutic purposes.

Autor: Crumbliss AL; Duke University Department of Chemistry, Durham, NC 27708-0346, USA. Electronic address: alvin.crumbliss@duke.edu., Banerjee S; Department of Chemistry, East Carolina University, Greenville, NC 27858, USA.
Jazyk: angličtina
Zdroj: Journal of inorganic biochemistry [J Inorg Biochem] 2021 Jun; Vol. 219, pp. 111411. Date of Electronic Publication: 2021 Mar 20.
DOI: 10.1016/j.jinorgbio.2021.111411
Abstrakt: The use of Ga 3+ as a structural mimic for Fe 3+ in model bioinorganic investigations is usually based on a common assumption that Ga 3+ and Fe 3+ should form bioligand complexes of similar stabilities due to their similar charge/radius ratio (z/r). However, the literature survey presented here is contrary to this notion, showing that under laboratory conditions often Ga 3+ forms weaker bioligand complexes than Fe 3+ in aqueous medium. We hypothesize that this is because Ga 3+ is more aquaphilic than Fe 3+ as suggested by their relative heats of hydration (ΔH hyd ). The successful use of Ga 3+ as a therapeutic agent is also briefly reviewed, showing this success often stems from the redox inertness as well as different pharmacokinetics of Ga 3+ than Fe 3+ , but similar metabolic pathways as Fe 3+ in human serum.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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