The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites.

Autor: Gupta Y; Infectious Diseases, Mayo Clinic, Jacksonville, Florida, 32224, USA., Goicoechea S; Stritch School of Medicine, Loyola University Chicago, Chicago, Illinois, USA., Pearce CM; Stritch School of Medicine, Loyola University Chicago, Chicago, Illinois, USA., Mathur R; Stritch School of Medicine, Loyola University Chicago, Chicago, Illinois, USA., Romero JG; Stritch School of Medicine, Loyola University Chicago, Chicago, Illinois, USA., Kwofie SK; Department of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, West African Center for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic & Applied Sciences, University of Ghana, Accra, Ghana., Weyenberg MC; Stritch School of Medicine, Loyola University Chicago, Chicago, Illinois, USA., Daravath B; Stritch School of Medicine, Loyola University Chicago, Chicago, Illinois, USA., Sharma N; Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi, India., Poonam; Department of Chemistry, Miranda House University Enclave, University of Delhi, Delhi, India., Akala HM; Kenya Medical Research Institute (KEMRI), Kisumu, Kenya., Kanzok SM; Department of Biology, Loyola University Chicago, Chicago, Illinois, USA., Durvasula R; Infectious Diseases, Mayo Clinic, Jacksonville, Florida, 32224, USA., Rathi B; Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi, India., Kempaiah P; Infectious Diseases, Mayo Clinic, Jacksonville, Florida, 32224, USA.
Jazyk: angličtina
Zdroj: Medicinal research reviews [Med Res Rev] 2022 Jan; Vol. 42 (1), pp. 56-82. Date of Electronic Publication: 2021 Apr 13.
DOI: 10.1002/med.21804
Abstrakt: Calcium channels (CCs), a group of ubiquitously expressed membrane proteins, are involved in many pathophysiological processes of protozoan parasites. Our understanding of CCs in cell signaling, organelle function, cellular homeostasis, and cell cycle control has led to improved insights into their structure and functions. In this article, we discuss CCs characteristics of five major protozoan parasites Plasmodium, Leishmania, Toxoplasma, Trypanosoma, and Cryptosporidium. We provide a comprehensive review of current antiparasitic drugs and the potential of using CCs as new therapeutic targets. Interestingly, previous studies have demonstrated that human CC modulators can kill or sensitize parasites to antiparasitic drugs. Still, none of the parasite CCs, pumps, or transporters has been validated as drug targets. Information for this review draws from extensive data mining of genome sequences, chemical library screenings, and drug design studies. Parasitic resistance to currently approved therapeutics is a serious and emerging threat to both disease control and management efforts. In this article, we suggest that the disruption of calcium homeostasis may be an effective approach to develop new anti-parasite drug candidates and reduce parasite resistance.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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