Aesculus hippocastanum -Derived Extract β-Aescin and In vitro Antibacterial Activity.

Autor:	Dahash SL; Department of Medical Microbiology, College of Medicine, Almustansiriya University, Baghdad, Iraq., Abass OK; Department of Medical Microbiology, College of Medicine, Almustansiriya University, Baghdad, Iraq., Abdul-Razaq MM; Department of Medical Microbiology, College of Medicine, Almustansiriya University, Baghdad, Iraq., Al-Kuraishy HM; Department of Medical Microbiology, College of Medicine, Almustansiriya University, Baghdad, Iraq., Al-Gareeb AI; Department of Medical Microbiology, College of Medicine, Almustansiriya University, Baghdad, Iraq.
Jazyk:	angličtina
Zdroj:	Journal of microscopy and ultrastructure [J Microsc Ultrastruct] 2021 Jan 09; Vol. 9 (1), pp. 26-30. Date of Electronic Publication: 2021 Jan 09 (Print Publication: 2021).
DOI:	10.4103/JMAU.JMAU_56_19
Abstrakt:	Objectives: The objective of this study was to investigate the antibacterial activity of β-aescin against common Gram-negative and Gram-positive bacteria. Materials and Methods: Agar well diffusion assay was used to determine the antibacterial activity of β-aescin against common Gram-negative and Gram-positive bacteria including Klebsiella pneumoniae, Escherichia coli, Staphylococcus epidermidis, Staphylococcus aureus, and Pseudomonas aeruginosa . Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of β-aescin were evaluated by serial dilution method. Results: β-aescin led to significant antibacterial effects on the tested Gram-negative and Gram-positive bacteria compared to the negative control, P < 0.05 for K. pneumoniae and P. aeruginosa and P < 0.01 for E. coli, S. epidermidis, and S. aureus . On the other hand, β-aescin produced a comparable less antibacterial effect on K. pneumoniae, E. coli, and P. aeruginosa compared to the positive control, P < 0.01, whereas β-aescin illustrated a comparable effect with that of the positive control on Gram-positive S. epidermidis, P = 0.05. Furthermore, β-aescin illustrated a concentration-dependent antibacterial effect against Gram-positive S. epidermidis and S. aureus compared to the different concentrations, P < 0.01. MIC and MBC of β-aescin were high for Gram-negative bacteria and low for Gram-positive bacteria compared to MIC of the positive control. Conclusions: β-aescin is an effective antibacterial herb mainly against Gram-positive S. epidermidis and S. aureus in a concentration-dependent manner. Competing Interests: There are no conflicts of interest. (Copyright: © 2021 Journal of Microscopy and Ultrastructure.)
Databáze:	MEDLINE
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