Ameliorative effect of apelin-13 against renal complications in L-NAME-induced preeclampsia in rats.

Autor:	Hamza RZ; Biology Department, College of Sciences, Taif University, Taif, Taif, Saudi Arabia., Diab AAA; Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt., Zahra MH; Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt., Asalah AK; Medical Physiology Department - Faculty of Human Medicine, Zagazig University, Zagazig, Egypt., Attia MS; Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt., Moursi SM; Medical Physiology Department - Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.
Jazyk:	angličtina
Zdroj:	PeerJ [PeerJ] 2021 Mar 31; Vol. 9, pp. e11110. Date of Electronic Publication: 2021 Mar 31 (Print Publication: 2021).
DOI:	10.7717/peerj.11110
Abstrakt:	Pre-eclampsia (PE) accompanying acute liver and kidney injury has remained a master cause of both fetal and maternal mortality and morbidity. Vasoactive mediators, oxidative stress and inflammatory imbalanceshave an important role in PE pathogenesis. Apelin is an adipokine that improves endothelial dysfunction; has anti-inflammatory and antioxidant effects; moreover, its level reduced during PE. This study aimed to explore the effects of apelin-13 administration on preeclampsia-associated renal dysfunction and proteinuria. Thirty-three pregnant female rats were divided into three groups; group: 1 (normal pregnant rats), group: 2 (preeclamptic rats); where rats were injected subcutaneously with 75 mg L-NAME/ kg body weight/day beginning from 9th to 20th day of pregnancy andgroup 3 (apelin-13 treated preeclamptic rats); In which L-NAME-induced preeclamptic rats were subcutaneously injected with 6 × 10 -8  mol apelin-13/kg body weight/twice daily starting from 6th to 20th day of pregnancy. In all groups, mean arterial blood pressure, total urine protein, serum urea, creatinine, nitric oxide (NO), endothelin-1 (ET-1), interleukin-6 (IL-6) and malondialdhyde (MDA) were measured. Histopathological examination of kidney tissues was also done. preeclamptic rats showed significantly increased mean arterial blood pressure, total urine proteins, serum urea, creatinine, ET-1, IL-6, and MDA, but revealed a significantly decreased serum NO level. On the other hand, apelin treatment significantly improved these parameters together with amelioration of kidney histoarchitecture in the treated group. In conclusion, apelin may be a potentially curative candidate for prohibiting kidney damage and have a therapeutic benefit in PE rat models. Competing Interests: The authors declare there are no competing interests. (©2021 Hamza et al.)
Databáze:	MEDLINE
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