Enhanced oral bioavailability and gastroprotective effect of ibuprofen through mixed polymer-lipid nanoparticles.
| Autor: | Al-Thamarani S; Department of Pharmacy, Faculty of Medicine & Health Sciences, Thamar University, Yemen., Gardouh A; Department of Pharmaceutics & Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Jadara University, Irbid 21110, Jordan. |
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| Jazyk: | angličtina |
| Zdroj: | Therapeutic delivery [Ther Deliv] 2021 May; Vol. 12 (5), pp. 363-374. Date of Electronic Publication: 2021 Apr 14. |
| DOI: | 10.4155/tde-2020-0125 |
| Abstrakt: | Objectives: The aim of this study was to design and formulate mixed polymer-lipid nanoparticles (PLNs) for the delivery of ibuprofen. Methods: The mixed PLNs were prepared by a single modified emulsification solvent evaporation method. Key findings: Core-shell-shaped mixed PLNs were successfully prepared, with sizes in the nano range (193.3 ± 0.70 to 795.8 ± 0.70 nm) and ζ potential (-26.8 ± 0.45 to -42.8 ± 0.30 mV). Entrapment efficiency ranged from 80.3 to 93.6%. Conclusions: Pharmacokinetic parameters showed great improvement in C |
| Databáze: | MEDLINE |
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