[Levels of 25 hydroxy vitamin D of serum and broncho-alveolar lavage in patients with pulmonary tuberculosis].

Autor:	Ramírez-Ramos CF; Departamento de Cardiología, Universidad Surcolombiana, Neiva, Colombia., Salamanca-Montilla JF; Departamento de Cardiología, Universidad de Antioquia, Medellín, Colombia., Herrera-Céspedes E; Universidad Nacional de Colombia, Bogotá D.C., Colombia., Rivera-Marín JD; Universidad Nacional de Colombia, Bogotá D.C., Colombia., Losada-Vanegas PX; Departamento de Ciencias Básicas Biomédicas, Universidad de Antioquia, Medellín, Colombia., Areiza-Paramo JD; Universidad Nacional de Colombia, Bogotá D.C., Colombia., Gutiérrez-Ramírez DR; Universidad Nacional de Colombia, Bogotá D.C., Colombia., Becerra-Meneces N; Universidad Nacional de Colombia, Bogotá D.C., Colombia., Méndez Díaz JL; Universidad Nacional de Colombia, Bogotá D.C., Colombia., Cuellar Azuero MI; Universidad Nacional de Colombia, Bogotá D.C., Colombia., Pinzón-Tovar A; Departamento de Medicina Interna y Endocrinología, Universidad Surcolombiana, Neiva, Colombia., Lastra-Lastra G; Universidad Nacional de Colombia, Bogotá D.C., Colombia., Lastra-González G; Departamento de Medicina Interna y Neumología, Universidad Surcolombiana, Neiva, Colombia.
Jazyk:	Spanish; Castilian
Zdroj:	Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia [Rev Chilena Infectol] 2021 Feb; Vol. 38 (1), pp. 37-44.
DOI:	10.4067/S0716-10182021000100037
Abstrakt:	Background: Alteration of vitamin D is a risk factor for tuberculosis (TB). Aim: To evaluate the pulmonary and serum levels of 25-hydroxy vitamin D (25OHD) in patients with and without pulmonary TB. Methods: Two-stage study: the first part was retrospective cross-sectional and the second prospective. Those > 18 years of age who underwent fiberoptic bronchoscopy for suspected pulmonary TB and in whom the infection was confirmed were included. Patients with another type of infection without TB and non-infectious diseases were taken as controls for the first stage and infectious controls without TB in the prospective phase. The measurement of 25OHD was performed by ELFA (enzyme-linked fluorescence assay). The Kruskal-Wallis test was used to evaluate association, considering a value of p < 0.05 to be significant. The data were processed with the SPSS version 23 program. Results: The total sample was 77 patients (35 in the first stage and 42 in the second). The characteristics between the groups were homogeneous. Serum (second phase) and broncho-alveolar lavage (first and second phase) levels of 25OHD were lower in TB patients compared to controls and were independent of serum calcium level (serum: 22.4 ng/mL vs 33 ng/mL, p = 0.006 and broncho-alveolar lavage: 9.7 ng/mL vs 12.2 ng/mL; p = 0.012). Conclusions: There was a significant difference between the levels of 25OHD in both serum and broncho-alveolar lavage in patients with pulmonary TB in relation to their controls.
Databáze:	MEDLINE
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