Broad-Spectrum Solvent-free Layered Black Phosphorus as a Rapid Action Antimicrobial.

Autor:	Shaw ZL; School of Engineering, RMIT University, Melbourne 3001, Victoria, Australia., Kuriakose S; Functional Materials and Microsystems Research Group and Micro Nano Research Facility, RMIT University, Melbourne 3001, Victoria, Australia., Cheeseman S; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne 3001, Victoria, Australia., Mayes ELH; RMIT Microscopy and Microanalysis Facility (RMMF), RMIT University, Melbourne 3000, Victoria, Australia., Murali A; Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn 3122, Victoria, Australia.; CSIRO Biomedical Manufacturing, Clayton 3168, Victoria, Australia., Oo ZY; Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn 3122, Victoria, Australia.; CSIRO Biomedical Manufacturing, Clayton 3168, Victoria, Australia., Ahmed T; Functional Materials and Microsystems Research Group and Micro Nano Research Facility, RMIT University, Melbourne 3001, Victoria, Australia.; Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, Pakistan., Tran N; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne 3001, Victoria, Australia., Boyce K; School of Science, RMIT University, Bundoora, Victoria 3083, Australia., Chapman J; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne 3001, Victoria, Australia., McConville CF; Deakin University, Geelong, Australia., Crawford RJ; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne 3001, Victoria, Australia., Taylor PD; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne 3001, Victoria, Australia., Christofferson AJ; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne 3001, Victoria, Australia., Truong VK; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne 3001, Victoria, Australia., Spencer MJS; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne 3001, Victoria, Australia., Elbourne A; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne 3001, Victoria, Australia., Walia S; School of Engineering, RMIT University, Melbourne 3001, Victoria, Australia.; Functional Materials and Microsystems, Research Group and Micro Nano Research Facility, RMIT University, Melbourne 3001, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Apr 21; Vol. 13 (15), pp. 17340-17352. Date of Electronic Publication: 2021 Apr 12.
DOI:	10.1021/acsami.1c01739
Abstrakt:	Antimicrobial resistance has rendered many conventional therapeutic measures, such as antibiotics, ineffective. This makes the treatment of infections from pathogenic micro-organisms a major growing health, social, and economic challenge. Recently, nanomaterials, including two-dimensional (2D) materials, have attracted scientific interest as potential antimicrobial agents. Many of these studies, however, rely on the input of activation energy and lack real-world utility. In this work, we present the broad-spectrum antimicrobial activity of few-layered black phosphorus (BP) at nanogram concentrations. This property arises from the unique ability of layered BP to produce reactive oxygen species, which we harness to create this unique functionality. BP is shown to be highly antimicrobial toward susceptible and resistant bacteria and fungal species. To establish cytotoxicity with mammalian cells, we showed that both L929 mouse and BJ-5TA human fibroblasts were metabolically unaffected by the presence of BP. Finally, we demonstrate the practical utility of this approach, whereby medically relevant surfaces are imparted with antimicrobial properties via functionalization with few-layer BP. Given the self-degrading properties of BP, this study demonstrates a viable and practical pathway for the deployment of novel low-dimensional materials as antimicrobial agents without compromising the composition or nature of the coated substrate.
Databáze:	MEDLINE
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