Esophageal disease among childhood cancer survivors-A report from the Childhood Cancer Survivors Study.

Autor: Asdahl PH; Department of Hematology Oeffinger, Aarhus University Hospital, Aarhus, Denmark., Oeffinger KC; Department of Medicine, Duke Cancer Institute, Durham, North Carolina, USA., Albieri V; Unit of Statistics and Data Analysis, Danish Cancer Society Research Center, Copenhagen, Denmark., Hudson M; Departments of Oncology and Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee, USA., Leisenring WM; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Donaldson SS; Department of Radiation Oncology, Stanford University, Stanford, California, USA., Hasle H; Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark., Winther JF; Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark., Armstrong GT; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee, USA., Robison LL; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2021 Aug; Vol. 68 (8), pp. e29043. Date of Electronic Publication: 2021 Apr 12.
DOI: 10.1002/pbc.29043
Abstrakt: There is limited information addressing the occurrence of esophageal strictures among the growing population of survivors of childhood cancer. Using the Childhood Cancer Survivor Study, we analyzed data from 17,121 5-year survivors and 3400 siblings to determine the prevalence and risk factors for esophageal strictures. Prevalence among survivors was 2.0% (95% confidence interval [CI]: 1.8-2.2%), representing a 7.6-fold increased risk compared to siblings. Factors significantly associated with risk of esophageal stricture included diagnosis of Hodgkin lymphoma, greater chest radiation dose, younger age at cancer diagnosis, platinum chemotherapy, and hematopoietic stem cell transplantation. While uncommon, survivors are at risk for therapy-related esophageal strictures.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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