Dementia, Subtype of Seizures, and the Risk of New Onset Seizures: A Cohort Study.

Autor:	Habeych ME; Dayton Children's Hospital, Division of Pediatric Neurology, Dayton, OH, USA., Falcone T; Cleveland Clinic Foundation, Neurological Institute, Epilepsy Center, Departments of Psychiatry and Psychology, Cleveland, OH, USA., Dagar A; Cleveland Clinic Foundation, Neurological Institute, Epilepsy Center, Departments of Psychiatry and Psychology, Cleveland, OH, USA., Ford L; Janssen Research & Development LLC, Hopewell, NJ, USA., Castilla-Puentes R; Janssen Research & Development LLC, Hopewell, NJ, USA.; Center for Clinical and Translational Science and Training, University of Cincinnati Academic Health Center, Cincinnati, OH, USA.; WARMI Mental Health, Collaborative Mental Health Network, Cincinnati, OH, USA.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2021; Vol. 81 (3), pp. 973-980.
DOI:	10.3233/JAD-210028
Abstrakt:	Background: Seizure disorders have been identified in patients suffering from different types of dementia. However, the risks associated with the seizure subtypes have not been characterized. Objective: To compare the occurrence and risk of various seizure subtypes (focal and generalized) between patients with and without a dementia diagnosis. Methods: Data from 40.7 million private insured patient individual electronic health records from the U.S., were utilized. Patients 60 years of age or more from the Optum Insight Clinformatics-data Mart database were included in this study. Using ICD-9 diagnoses, the occurrence of generalized or focal seizure disorders was identified. The risk of new-onset seizures and the types of seizures associated with a dementia diagnosis were estimated in a cohort of 2,885,336 patients followed from 2005 to 2014. Group differences were analyzed using continuity-adjusted chi-square and hazard ratios with 95%confidence intervals calculated after a logistic regression analysisResults:A total of 79,561 patient records had a dementia diagnosis, and 56.38%of them were females. Patients with dementia when compared to those without dementia had higher risk for seizure disorders [Hazard ratio (HR) = 6.5 95%CI = 4.4-9.5]; grand mal status (HR = 6.5, 95%CI = 5.7-7.3); focal seizures (HR = 6.0, 95%CI = 5.5-6.6); motor simple focal status (HR = 5.6, 95%CI = 3.5-9.0); epilepsy (HR = 5.0, 95%CI = 4.8-5.2); generalized convulsive epilepsy (HR = 4.8, 95%CI = 4.5-5.0); localization-related epilepsy (HR = 4.5, 95%CI = 4.1-4.9); focal status (HR = 4.2, 95%CI = 2.9-6.1); and fits convulsions (HR = 3.5, 95%CI = 3.4-3.6). Conclusion: The study confirms that patients with dementia have higher risks of generalized or focal seizure than patients without dementia.
Databáze:	MEDLINE
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