Children With Autism Spectrum Disorder and Neurodevelopmental Regression Present a Severe Pattern After a Follow-Up at 24 Months.

Autor:	Martin-Borreguero P; Unit of Psychology and Paediatric Psychiatry, Reina Sofia University Hospital, Cordoba, Spain., Gómez-Fernández AR; Department of Paediatrics, Infanta Margarita Hospital, Cabra, Córdoba, Spain.; Department of Paediatrics, Reina Sofia University Hospital, Córdoba University, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Córdoba, Spain., De La Torre-Aguilar MJ; Department of Paediatrics, Reina Sofia University Hospital, Córdoba University, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Córdoba, Spain., Gil-Campos M; Department of Paediatrics, Reina Sofia University Hospital, Córdoba University, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Córdoba, Spain.; Centre for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain., Flores-Rojas K; Centre for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain.; Paediatric Research Unit, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), CIBERObn, Córdoba, Spain., Perez-Navero JL; Department of Paediatrics, Reina Sofia University Hospital, Córdoba University, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Córdoba, Spain.; Centre for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2021 Mar 26; Vol. 12, pp. 644324. Date of Electronic Publication: 2021 Mar 26 (Print Publication: 2021).
DOI:	10.3389/fpsyt.2021.644324
Abstrakt:	This study examined the presence of neurodevelopmental regression and its effects on the clinical manifestations and the severity of autism spectrum disorder (ASD) in a group of children with autism compared with those without neurodevelopmental regression at the time of initial classification and subsequently. Methods and Subjects: ASD patients were classified into two subgroups, neurodevelopmental regressive (AMR) and non-regressive (ANMR), using a questionnaire based on the Autism Diagnostic Interview-Revised test. The severity of ASD and neurodevelopment were assessed with the Childhood Autism Rating Scale Test-2, Strengths and Difficulties Questionnaire , and Pervasive Developmental Disorders Behavior Inventory Parent Ratings (PDDBI) and with the Battelle Developmental Inventory tests at the beginning of the study and after 24 months of follow-up. Fifty-two patients aged 2-6 years with ASD were included. Nineteen were classified with AMR, and 33 were classified with ANMR. Results: The AMR subgroup presented greater severity of autistic symptoms and higher autism scores. Additionally, they showed lower overall neurodevelopment. The AMR subgroup at 24 months had poorer scores on the Battelle Developmental Inventory test in the following areas: Total personal/social ( p < 0.03), Total Motor ( p < 0.04), Expressive ( p < 0.01), and Battelle Total ( p < 0.04). On the PDDBI test, the AMR subgroup had scores indicating significantly more severe ASD symptoms in the variables: ritual score ( p < 0.038), social approach behaviors ( p < 0.048), expressive language ( p < 0.002), and autism score ( p < 0.003). Conclusions: ASD patients exhibited a set of different neurological phenotypes. The AMR and ANMR subgroups presented different clinical manifestations and prognoses in terms of the severity of autistic symptoms and neurodevelopment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Martin-Borreguero, Gómez-Fernández, De La Torre-Aguilar, Gil-Campos, Flores-Rojas and Perez-Navero.)
Databáze:	MEDLINE
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