The Acute Onset of Autoimmune Hepatitis During Pregnancy in the Absence of Hypergammaglobulinemia and Autoantibodies.

Autor:	Kawada A; Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan., Iwamura S; Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan., Yorita K; Department of Diagnostic Pathology, Japanese Red Cross Kochi Hospital, Japan., Daike R; Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan., Tanaka Y; Department of Obstetrics and Gynecology, Japanese Red Cross Kochi Hospital, Japan., Kuroda N; Department of Internal Medicine, Kobe Kyodo Hospital, Japan., Zen Y; Institute of Liver Studies, King's College Hospital and King's College London, UK., Okazaki M; Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan., Uchita K; Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan.
Jazyk:	angličtina
Zdroj:	Internal medicine (Tokyo, Japan) [Intern Med] 2021 Oct 15; Vol. 60 (20), pp. 3231-3237. Date of Electronic Publication: 2021 Apr 12.
DOI:	10.2169/internalmedicine.7155-21
Abstrakt:	The onset of autoimmune hepatitis (AIH) during pregnancy is rare and often poses a diagnostic challenge. A 29-year-old Japanese woman experienced epigastric pain and nausea during the third trimester of her third pregnancy. Three days after the symptom onset, an emergency Caesarean section was performed because of suspected acute fatty liver of pregnancy; however, the patient's liver dysfunction worsened afterward. Despite normal serum IgG concentration and absence of autoantibodies, biopsy-proven severe hepatitis with centrilobular zonal necrosis and good biochemical response to corticosteroids led to a diagnosis of AIH. Therefore, AIH should be included in the differential diagnosis of liver dysfunction during pregnancy.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu