Highly pathogenic avian influenza virus H5N6 (clade 2.3.4.4b) has a preferable host tropism for waterfowl reflected in its inefficient transmission to terrestrial poultry.

Autor: Seekings AH; Avian Virology and Mammalian Influenza Research, Virology Department, Animal and Plant Health Agency (APHA-Weybridge), Addlestone, Surrey, KT15 3NB, UK., Warren CJ; Avian Virology and Mammalian Influenza Research, Virology Department, Animal and Plant Health Agency (APHA-Weybridge), Addlestone, Surrey, KT15 3NB, UK., Thomas SS; Avian Virology and Mammalian Influenza Research, Virology Department, Animal and Plant Health Agency (APHA-Weybridge), Addlestone, Surrey, KT15 3NB, UK., Mahmood S; Avian Virology and Mammalian Influenza Research, Virology Department, Animal and Plant Health Agency (APHA-Weybridge), Addlestone, Surrey, KT15 3NB, UK., James J; Avian Virology and Mammalian Influenza Research, Virology Department, Animal and Plant Health Agency (APHA-Weybridge), Addlestone, Surrey, KT15 3NB, UK., Byrne AMP; Avian Virology and Mammalian Influenza Research, Virology Department, Animal and Plant Health Agency (APHA-Weybridge), Addlestone, Surrey, KT15 3NB, UK., Watson S; Animal Sciences Unit, APHA-Weybridge, Addlestone, Surrey, KT15 3NB, UK., Bianco C; Pathology Department, APHA-Weybridge, Addlestone, Surrey, KT15 3NB, UK., Nunez A; Pathology Department, APHA-Weybridge, Addlestone, Surrey, KT15 3NB, UK., Brown IH; Avian Virology and Mammalian Influenza Research, Virology Department, Animal and Plant Health Agency (APHA-Weybridge), Addlestone, Surrey, KT15 3NB, UK., Brookes SM; Avian Virology and Mammalian Influenza Research, Virology Department, Animal and Plant Health Agency (APHA-Weybridge), Addlestone, Surrey, KT15 3NB, UK., Slomka MJ; Avian Virology and Mammalian Influenza Research, Virology Department, Animal and Plant Health Agency (APHA-Weybridge), Addlestone, Surrey, KT15 3NB, UK. Electronic address: marek.slomka@apha.gov.uk.
Jazyk: angličtina
Zdroj: Virology [Virology] 2021 Jul; Vol. 559, pp. 74-85. Date of Electronic Publication: 2021 Mar 25.
DOI: 10.1016/j.virol.2021.03.010
Abstrakt: Highly-pathogenic avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) incurred into Europe in late 2017 and was predominantly detected in wild birds, with very few terrestrial poultry cases. Pekin ducks directly-infected with a UK virus (H5N6-2017) were donors of infection to investigate contact transmission to three recipient species: Ducks, chickens and turkeys. H5N6-2017 transmission to ducks was 100% efficient, but transmission to in-contact galliforme species was infrequent and unpredictable, thereby reflecting the European 2017-2018 H5N6 epidemiology. Although only two of 28 (7%) infected ducks died, the six turkeys and one chicken which became infected all died and displayed systemic H5N6-2017 dissemination, while pathogenesis in ducks was generally milder. Analysis of H5N6-2017 progeny in the contacts revealed no emergent polymorphisms in an infected duck, but the galliforme species included changes in the polymerase (PB2 A199T, PA D347A), matrix (M1 T218A) and neuraminidase genes (T88I). H5N6-2017 environmental contamination was associated with duck shedding.
(Crown Copyright © 2021. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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