Systemic immunity in cancer.

Autor: Hiam-Galvez KJ; Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.; Graduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, San Francisco, CA, USA., Allen BM; Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.; Graduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, San Francisco, CA, USA., Spitzer MH; Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA. matthew.spitzer@ucsf.edu.; Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA. matthew.spitzer@ucsf.edu.; Graduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA, USA. matthew.spitzer@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. matthew.spitzer@ucsf.edu.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. matthew.spitzer@ucsf.edu.; Chan Zuckerberg Biohub, San Francisco, San Francisco, CA, USA. matthew.spitzer@ucsf.edu.
Jazyk: angličtina
Zdroj: Nature reviews. Cancer [Nat Rev Cancer] 2021 Jun; Vol. 21 (6), pp. 345-359. Date of Electronic Publication: 2021 Apr 09.
DOI: 10.1038/s41568-021-00347-z
Abstrakt: Immunotherapy has revolutionized cancer treatment, but efficacy remains limited in most clinical settings. Cancer is a systemic disease that induces many functional and compositional changes to the immune system as a whole. Immunity is regulated by interactions of diverse cell lineages across tissues. Therefore, an improved understanding of tumour immunology must assess the systemic immune landscape beyond the tumour microenvironment (TME). Importantly, the peripheral immune system is required to drive effective natural and therapeutically induced antitumour immune responses. In fact, emerging evidence suggests that immunotherapy drives new immune responses rather than the reinvigoration of pre-existing immune responses. However, new immune responses in individuals burdened with tumours are compromised even beyond the TME. Herein, we aim to comprehensively outline the current knowledge of systemic immunity in cancer.
Databáze: MEDLINE
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