Severe Preeclampsia is Associated with Functional and Structural Cardiac Alterations: A Case-control Study.

Autor:	Kilic D; Department of Obstetrics and Gynecology, Pamukkale University, Denizli, Turkey., Guler T; Department of Obstetrics and Gynecology, Pamukkale University, Denizli, Turkey., Sevgican CI; Department of Cardiology, Pamukkale University, Denizli, Turkey., Atigan A; Department of Obstetrics and Gynecology, Sanliurfa Viransehir State Hospital, Sanliurfa, Turkey., Kilic O; Department of Cardiology, Simav Doc. Ismail Karakuyu State Hospital, Kutahya, Turkey., Kaya D; Department of Cardiology, Pamukkale University, Denizli, Turkey., Kilic ID; Department of Cardiology, Pamukkale University, Denizli, Turkey.
Jazyk:	angličtina
Zdroj:	Zeitschrift fur Geburtshilfe und Neonatologie [Z Geburtshilfe Neonatol] 2022 Feb; Vol. 226 (1), pp. 41-47. Date of Electronic Publication: 2021 Apr 09.
DOI:	10.1055/a-1403-3585
Abstrakt:	Background: The aim of the current study is to compare electrocardiographic and echocardiographic changes in patients with severe preeclampsia (PE) and those with uncomplicated pregnancies. Methods: This is a case-controlled prospective study consisting of 21 pregnant women with severe preeclampsia and a control group consisting of age- and gestational age-matched 24 healthy pregnant women. All patients underwent electrocardiographic and echocardiographic investigation. Results: QRS intervals were shorter and PR intervals were longer in the PE group (QRS duration: 80 (60-120) ms and 80 (40-110) ms, p=0.035; PR duration: 160 (100-240) ms and 120 (80-200) ms, respectively; p=0.046). The left ventricular end-systolic diameters of the patients with severe PE group were significantly larger than the control group (31 (24-36) mm and 30 (24-33) mm, respectively; p=0.05). Similarly, posterior wall thickness values of the PE group were significantly higher compared to the control group (9 (7-11) mm vs. 8 (6-10) mm, respectively; p=0.020). Left ventricular mass (146.63±27.73 g and 128.69±23.25 g, respectively; p=0.033) and relative wall thickness values (0.385±0.054 and 0.349±0.046, respectively; p=0.030) were also higher in the PE group. In addition, patients with early-onset severe PE had significantly a higher left ventricular end-diastolic diameter and volume compared with late-onset PE patients. Conclusions: The structural changes detected in the severe PE group suggest a chronic process rather than an acute effect. In addition, diastolic dysfunction and left ventricular remodeling are most marked in patients with severe early-onset PE. Competing Interests: The authors declare that they have no conflict of interest. (Thieme. All rights reserved.)
Databáze:	MEDLINE
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