Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.

Autor:	Serrano-Lopez J; Divisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States., Hegde S; Divisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.; Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, United States., Kumar S; Divisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States., Serrano J; Hematology Department, Reina Sofía University Hospital/Maimonides Biomedical Research Institute of Córdoba (IMIBIC)/University of Córdoba, Córdoba, Spain., Fang J; Divisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States., Wellendorf AM; Divisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States., Roche PA; Center for Cancer Research, National Cancer Institute, Bethesda, United States.; Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States., Rangel Y; Hematology Department, Reina Sofía University Hospital/Maimonides Biomedical Research Institute of Córdoba (IMIBIC)/University of Córdoba, Córdoba, Spain., Carrington LJ; University of Pennsylvania Perelman School of Medicine, Philadelphia, United States., Geiger H; Divisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.; Institute of Molecular Medicine, Ulm University, Ulm, Germany., Grimes HL; Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States., Luther S; Center for Immunity and Infection, Department of Biochemistry, University of Lausanne, Epalinges, Switzerland., Maillard I; University of Pennsylvania Perelman School of Medicine, Philadelphia, United States., Sanchez-Garcia J; Hematology Department, Reina Sofía University Hospital/Maimonides Biomedical Research Institute of Córdoba (IMIBIC)/University of Córdoba, Córdoba, Spain., Starczynowski DT; Divisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.; Department of Cancer Biology, University of Cincinnati, Cincinnati, United States., Cancelas JA; Divisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.; Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2021 Apr 08; Vol. 10. Date of Electronic Publication: 2021 Apr 08.
DOI:	10.7554/eLife.66190
Abstrakt:	Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emergent activation of a previously unrecognized system of rapid migration of granulocyte-macrophage progenitors and committed macrophage-dendritic progenitors, but not other progenitors or stem cells, from bone marrow (BM) to regional lymphatic capillaries. The progenitor traffic to the systemic lymphatic circulation is mediated by Ccl19/Ccr7 and is NF-κB independent, Traf6/IκB-kinase/SNAP23 activation dependent, and is responsible for the secretion of pre-stored Ccl19 by a subpopulation of CD205 + /CD172a + conventional dendritic cells type 2 and upregulation of BM myeloid progenitor Ccr7 signaling. Mature myeloid Traf6 signaling is anti-inflammatory and necessary for lymph node myeloid cell development. This report unveils the existence and the mechanistic basis of a very early direct traffic of myeloid progenitors from BM to lymphatics during inflammation. Competing Interests: JS, SH, SK, JS, JF, AW, PR, YR, LC, HG, HG, SL, IM, JS, DS, JC No competing interests declared
Databáze:	MEDLINE
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