Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection.

Autor:	Jones NK; Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom.; Clinical Microbiology & Public Health Laboratory, Public Health England, Cambridge, United Kingdom., Rivett L; Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom.; Clinical Microbiology & Public Health Laboratory, Public Health England, Cambridge, United Kingdom., Seaman S; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom., Samworth RJ; Statistical Laboratory, Centre for Mathematical Sciences, University of Cambridge, Cambridge, United Kingdom., Warne B; Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom.; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Workman C; Occupational Health and Wellbeing, Cambridge Biomedical Campus, Cambridge, United Kingdom., Ferris M; Occupational Health and Wellbeing, Cambridge Biomedical Campus, Cambridge, United Kingdom., Wright J; Occupational Health and Wellbeing, Cambridge Biomedical Campus, Cambridge, United Kingdom., Quinnell N; Occupational Health and Wellbeing, Cambridge Biomedical Campus, Cambridge, United Kingdom., Shaw A; Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom., Goodfellow IG; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom., Lehner PJ; Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom.; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Howes R; Cambridge COVID-19 Testing Centre and AstraZeneca, Anne McLaren Building, Cambridge, United Kingdom., Wright G; Occupational Health and Wellbeing, Cambridge Biomedical Campus, Cambridge, United Kingdom., Matheson NJ; Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom.; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge, United Kingdom., Weekes MP; Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2021 Apr 08; Vol. 10. Date of Electronic Publication: 2021 Apr 08.
DOI:	10.7554/eLife.68808
Abstrakt:	The BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) is being utilised internationally for mass COVID-19 vaccination. Evidence of single-dose protection against symptomatic disease has encouraged some countries to opt for delayed booster doses of BNT162b2, but the effect of this strategy on rates of asymptomatic SARS-CoV-2 infection remains unknown. We previously demonstrated frequent pauci- and asymptomatic SARS-CoV-2 infection amongst healthcare workers (HCWs) during the UK's first wave of the COVID-19 pandemic, using a comprehensive PCR-based HCW screening programme (Rivett et al., 2020; Jones et al., 2020). Here, we evaluate the effect of first-dose BNT162b2 vaccination on test positivity rates and find a fourfold reduction in asymptomatic infection amongst HCWs ≥12 days post-vaccination. These data provide real-world evidence of short-term protection against asymptomatic SARS-CoV-2 infection following a single dose of BNT162b2 vaccine, suggesting that mass first-dose vaccination will reduce SARS-CoV-2 transmission , as well as the burden of COVID-19 disease . Competing Interests: NJ, LR, SS, RS, BW, CW, MF, JW, NQ, AS, IG, PL, GW, NM, MW No competing interests declared, RH Dr Howes was employed by AstraZeneca PLC during the period of study and preparation of this manuscript. (© 2021, Jones et al.)
Databáze:	MEDLINE
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