A systematic review and meta-analysis of Histoscanning™ in prostate cancer diagnostics.

Autor: Morozov A; Institute for Urology and Reproductive Health, Sechenov University, Bolshaya Pirogovskaya str. 2 bld. 1, Moscow, 119991, Russia., Kozlov V; Department of Public Health and Healthcare, Sechenov University, Moscow, Russia., Rivas JG; Department of Urology, Clinico San Carlos University Hospital, Madrid, Spain., Teoh JY; Department of Surgery, S.H. Ho Urology Centre, The Chinese University of Hong Kong, Hong Kong, China., Bezrukov E; Institute for Urology and Reproductive Health, Sechenov University, Bolshaya Pirogovskaya str. 2 bld. 1, Moscow, 119991, Russia., Amosov A; Institute for Urology and Reproductive Health, Sechenov University, Bolshaya Pirogovskaya str. 2 bld. 1, Moscow, 119991, Russia., Barret E; Department of Urology, Institut Mutualiste Montsouris, Paris, France., Taratkin M; Institute for Urology and Reproductive Health, Sechenov University, Bolshaya Pirogovskaya str. 2 bld. 1, Moscow, 119991, Russia., Salomon G; Martini Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Herrmann TRW; Department of Urology, Spital Thurgau AG, Pfaffenholzstrasse 4, 8501, Frauenfeld, Switzerland.; Department of Urology, Hannover Medical School, Hannover, Germany., Gozen A; SLK-Kliniken Urology Department, Heidelberg University, Heilbronn, Germany., Enikeev D; Institute for Urology and Reproductive Health, Sechenov University, Bolshaya Pirogovskaya str. 2 bld. 1, Moscow, 119991, Russia. dvenikeev@gmail.com.
Jazyk: angličtina
Zdroj: World journal of urology [World J Urol] 2021 Oct; Vol. 39 (10), pp. 3733-3740. Date of Electronic Publication: 2021 Apr 07.
DOI: 10.1007/s00345-021-03684-8
Abstrakt: Context: The value of Histoscanning™ (HS) in prostate cancer (PCa) imaging is much debated, although it has been used in clinical practice for more than 10 years now.
Objective: To summarize the data on HS from various PCa diagnostic perspectives to determine its potential.
Materials and Methods: We performed a systematic search using 2 databases (Medline and Scopus) on the query "Histoscan*". The primary endpoint was HS accuracy. The secondary endpoints were: correlation of lesion volume by HS and histology, ability of HS to predict extracapsular extension or seminal vesicle invasion.
Results: HS improved cancer detection rate "per core", OR = 16.37 (95% CI 13.2; 20.3), p < 0.0001, I 2  = 98% and "per patient", OR = 1.83 (95% CI 1.51; 2.21), p < 0.0001, I 2  = 95%. The pooled accuracy was markedly low: sensitivity - 0.2 (95% CI 0.19-0.21), specificity - 0.12 (0.11-0.13), AUC 0.12. 8 of 10 studiers showed no additional value for HS. The pooled accuracy with histology after RP was relatively better, yet still very low: sensitivity - 0.56 (95% CI 0.5-0.63), specificity - 0.23 (0.18-0.28), AUC 0.4. 9 of 12 studies did not show any benefit of HS.
Conclusion: This meta-analysis does not see the incremental value in comparing prostate Histoscanning with conventional TRUS in prostate cancer screening and targeted biopsy. HS proved to be slightly more accurate in predicting extracapsular extension on RP, but the available data does not allow us to draw any conclusions on its effectiveness in practice. Histoscanning is a modification of ultrasound for prostate cancer visualization. The available data suggest its low accuracy in screening and detecting of prostate cancer.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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