Biologically consistent dose accumulation using daily patient imaging.

Autor: Niebuhr NI; Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. nina.niebuhr@med.uni-heidelberg.de.; Heidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany. nina.niebuhr@med.uni-heidelberg.de.; Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany. nina.niebuhr@med.uni-heidelberg.de., Splinter M; Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Heidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany., Bostel T; Clinical Cooperation Unit 'Radiation Oncology', German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Radiation Oncology, University Medical Center Mainz, Mainz, Germany., Seco J; Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany.; Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hentschke CM; Heidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany., Floca RO; Heidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany., Hörner-Rieber J; Heidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Clinical Cooperation Unit 'Radiation Oncology', German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany., Alber M; Heidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany., Huber P; Clinical Cooperation Unit 'Radiation Oncology', German Cancer Research Center (DKFZ), Heidelberg, Germany.; Molecular Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Nicolay NH; Clinical Cooperation Unit 'Radiation Oncology', German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Radiation Oncology, Freiburg University Medical Center, Freiburg, Germany., Pfaffenberger A; Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Heidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.
Jazyk: angličtina
Zdroj: Radiation oncology (London, England) [Radiat Oncol] 2021 Apr 06; Vol. 16 (1), pp. 65. Date of Electronic Publication: 2021 Apr 06.
DOI: 10.1186/s13014-021-01789-3
Abstrakt: Background: This work addresses a basic inconsistency in the way dose is accumulated in radiotherapy when predicting the biological effect based on the linear quadratic model (LQM). To overcome this inconsistency, we introduce and evaluate the concept of the total biological dose, bEQD d .
Methods: Daily computed tomography imaging of nine patients treated for prostate carcinoma with intensity-modulated radiotherapy was used to compute the delivered deformed dose on the basis of deformable image registration (DIR). We compared conventional dose accumulation (DA) with the newly introduced bEQD d , a new method of accumulating biological dose that considers each fraction dose and tissue radiobiology. We investigated the impact of the applied fractionation scheme (conventional/hypofractionated), uncertainties induced by the DIR and by the assigned α/β-value.
Results: bEQD d was systematically higher than the conventionally accumulated dose with difference hot spots of 3.3-4.9 Gy detected in six out of nine patients in regions of high dose gradient in the bladder and rectum. For hypofractionation, differences are up to 8.4 Gy. The difference amplitude was found to be in a similar range to worst-case uncertainties induced by DIR and was higher than that induced by α/β.
Conclusion: Using bEQD d for dose accumulation overcomes a potential systematic inaccuracy in biological effect prediction based on accumulated dose. Highest impact is found for serial-type late responding organs at risk in dose gradient regions and for hypofractionation. Although hot spot differences are in the order of several Gray, in dose-volume parameters there is little difference compared with using conventional or biological DA. However, when local dose information is used, e.g. dose surface maps, difference hot spots can potentially change outcomes of dose-response modelling and adaptive treatment strategies.
Databáze: MEDLINE
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