New Insight into Vitamins E and K 1 as Anti-Quorum-Sensing Agents against Pseudomonas aeruginosa.
Autor: | Soltani S; Department of Microbiology, Faculty of Science, University of Mazandaran, Babolsar, Iran., Fazly Bazzaz BS; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran., Hadizadeh F; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran., Roodbari F; Department of Microbiology, Faculty of Science, University of Mazandaran, Babolsar, Iran., Soheili V; Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Soheiliv@mums.ac.ir. |
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Jazyk: | angličtina |
Zdroj: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 May 18; Vol. 65 (6). Date of Electronic Publication: 2021 May 18 (Print Publication: 2021). |
DOI: | 10.1128/AAC.01342-20 |
Abstrakt: | Today, antivirulence compounds that attenuate bacterial pathogenicity and have no interference with bacterial viability or growth are introduced as the next generation of antibacterial agents. However, the development of such compounds that can be used by humans is restricted by various factors, including the need for extensive economic investments, the inability of many molecules to penetrate the membrane of Gram-negative bacteria, and unfavorable pharmacological properties and cytotoxicity. Here, we take a new and different look into two frequent supplements, vitamin E and K (Copyright © 2021 American Society for Microbiology.) |
Databáze: | MEDLINE |
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