Building a biofoundry.

Autor: Holowko MB; CSIRO Synthetic Biology Future Science Platform, CSIRO Land and Water, Brisbane, QLD 4102, Australia., Frow EK; School for the Future of Innovation in Society and School of Biological & Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA., Reid JC; CSIRO Synthetic Biology Future Science Platform, CSIRO Land and Water, Brisbane, QLD 4102, Australia., Rourke M; CSIRO Synthetic Biology Future Science Platform, CSIRO Land and Water, Brisbane, QLD 4102, Australia.; Law Futures Centre, Griffith Law School, Griffith University, Nathan, QLD 4111, Australia., Vickers CE; CSIRO Synthetic Biology Future Science Platform, CSIRO Land and Water, Brisbane, QLD 4102, Australia.; ARC Centre of Excellence in Synthetic Biology, Queensland University of Technology, Brisbane, QLD 4001, Australia.
Jazyk: angličtina
Zdroj: Synthetic biology (Oxford, England) [Synth Biol (Oxf)] 2020 Dec 16; Vol. 6 (1), pp. ysaa026. Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2021).
DOI: 10.1093/synbio/ysaa026
Abstrakt: A biofoundry provides automation and analytics infrastructure to support the engineering of biological systems. It allows scientists to perform synthetic biology and aligned experimentation on a high-throughput scale, massively increasing the solution space that can be examined for any given problem or question. However, establishing a biofoundry is a challenging undertaking, with numerous technical and operational considerations that must be addressed. Using collated learnings, here we outline several considerations that should be addressed prior to and during establishment. These include drivers for establishment, institutional models, funding and revenue models, personnel, hardware and software, data management, interoperability, client engagement and biosecurity issues. The high cost of establishment and operation means that developing a long-term business model for biofoundry sustainability in the context of funding frameworks, actual and potential client base, and costing structure is critical. Moreover, since biofoundries are leading a conceptual shift in experimental design for bioengineering, sustained outreach and engagement with the research community are needed to grow the client base. Recognition of the significant, long-term financial investment required and an understanding of the complexities of operationalization is critical for a sustainable biofoundry venture. To ensure state-of-the-art technology is integrated into planning, extensive engagement with existing facilities and community groups, such as the Global Biofoundries Alliance, is recommended.
(© Crown copyright 2020.)
Databáze: MEDLINE
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