Genetic evidence for a large overlap and potential bidirectional causal effects between resilience and well-being.

Autor:	de Vries LP; Department of Biological Psychology, Vrije Universiteit Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Baselmans BML; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Luykx JJ; Department of Psychiatry, UMC Utrecht, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Outpatient Second Opinion Clinic, GGNet Mental Health, Warnsveld, the Netherlands., de Zeeuw EL; Department of Biological Psychology, Vrije Universiteit Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Minică CC; Department of Biological Psychology, Vrije Universiteit Amsterdam, the Netherlands.; Stanley Center for Psychiatric Disease, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA., de Geus EJC; Department of Biological Psychology, Vrije Universiteit Amsterdam, the Netherlands., Vinkers CH; Department of Psychiatry, Amsterdam UMC, Location VUmc, the Netherlands.; Department of Anatomy and Neurosciences, Amsterdam UMC, Location VUmc, the Netherlands., Bartels M; Department of Biological Psychology, Vrije Universiteit Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Amsterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	Neurobiology of stress [Neurobiol Stress] 2021 Mar 14; Vol. 14, pp. 100315. Date of Electronic Publication: 2021 Mar 14 (Print Publication: 2021).
DOI:	10.1016/j.ynstr.2021.100315
Abstrakt:	Resilience and well-being are strongly related. People with higher levels of well-being are more resilient after stressful life events or trauma and vice versa. Less is known about the underlying sources of overlap and causality between the constructs. In a sample of 11.304 twins and 2.572 siblings from the Netherlands Twin Register, we investigated the overlap and possible direction of causation between resilience (i.e. the absence of psychiatric symptoms despite negative life events) and well-being (i.e. satisfaction with life) using polygenic score (PGS) prediction, twin-sibling modelling, and the Mendelian Randomization Direction of Causality (MR-DoC) model. Longitudinal twin-sibling models showed significant phenotypic correlations between resilience and well-being (.41/.51 at time 1 and 2). Well-being PGS were predictive for both well-being and resilience, indicating that genetic factors influencing well-being also predict resilience. Twin-sibling modeling confirmed this genetic correlation (0.71) and showed a strong environmental correlation (0.93). In line with causality, both genetic (51%) and environmental (49%) factors contributed significantly to the covariance between resilience and well-being. Furthermore, the results of within-subject and MZ twin differences analyses were in line with bidirectional causality. Additionally, we used the MR-DoC model combining both molecular and twin data to test causality, while correcting for pleiotropy. We confirmed the causal effect from well-being to resilience, with the direct effect of well-being explaining 11% (T1) and 20% (T2) of the variance in resilience. Data limitations prevented us to test the directional effect from resilience to well-being with the MR-DoC model. To conclude, we showed a strong relation between well-being and resilience. A first attempt to quantify the direction of this relationship points towards a bidirectional causal effect. If replicated, the potential mutual effects can have implications for interventions to lower psychopathology vulnerability, as resilience and well-being are both negatively related to psychopathology. Competing Interests: Lianne de Vries, Bart Baselmans, Jurjen Luykx, Eveline de Zeeuw, Camelia Minica, Eco de Geus, Christiaan Vinkers and Meike Bartels declare no conflict of interest. (© 2021 The Authors.)
Databáze:	MEDLINE
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