| Autor: |
van't Verlaat JW; Department of Neurosurgery, University Hospital Utrecht, The Netherlands., Nortier JW, Hendriks MJ, Bosma NJ, Graamans K, Lubsen H, Vasen HF, Thijssen JH, Croughs RJ |
| Jazyk: |
angličtina |
| Zdroj: |
Acta endocrinologica [Acta Endocrinol (Copenh)] 1988 Feb; Vol. 117 (2), pp. 154-8. |
| DOI: |
10.1530/acta.0.1170154 |
| Abstrakt: |
Twenty-five patients with acromegaly were treated by transsphenoidal microsurgery. Fourteen patients (56%) were considered cured according to the following criteria: a. basal plasma GH less than 10 mU/l; b. glucose suppressed plasma GH less than or equal to 4 mU/l, and c. disappearance of TRH responsiveness if present preoperatively. Thirteen of the cured patients were re-evaluated after a mean follow-up period of 3.5 years (range 1.5 to 5.5 years). At that time, basal plasma GH was still less than 10 mU/l and glucose suppressed plasma GH was still less than or equal to 4 mU/l in all patients, indicating the practical value of our criteria. The remaining 11 patients (44%) received additional treatment by external pituitary irradiation and bromocriptine. Owing to surgery, 5 patients (20%) developed partial or panhypopituitarism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
