Have Volume-based Parameters of Positron Emission Tomography/Computed Tomography Prognostic Relevance for Patients With Potentially Platinum-responsive Recurrent Ovarian Cancer? A Single Center Italian Study.

Autor:	Gadducci A; Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy; a.gadducci@med.unipi.it., Simonetti E; Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy., Guidoccio F; Regional Center of Nuclear Medicine, Department of Translational Research, University of Pisa, Pisa, Italy., Manca G; Regional Center of Nuclear Medicine, Department of Translational Research, University of Pisa, Pisa, Italy., Giorgetti A; Fondazione CNR/Regione Toscana 'Gabriele Monasterio', Pisa, Italy., Depalo T; Regional Center of Nuclear Medicine, Department of Translational Research, University of Pisa, Pisa, Italy., Cosio S; Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy., Miccoli M; Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy., Volterrani D; Regional Center of Nuclear Medicine, Department of Translational Research, University of Pisa, Pisa, Italy.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2021 Apr; Vol. 41 (4), pp. 1937-1944.
DOI:	10.21873/anticanres.14960
Abstrakt:	Background/aim: To assess the prognostic relevance of volume-based parameters [whole body (wb)-metabolic tumor volume (MTV) and wb-total lesion glycolysis (TLG)] of pretreatment PET/CT in patients with potentially platinum-responsive recurrent ovarian cancer. Patients and Methods: This retrospective investigation analyzed 67 patients at first relapse. Results: At univariate analysis, post-relapse survival and overall survival correlated with residual disease after primary surgery (RD) (p=0.015 and 0.049, respectively), time to recurrence (p=0.005 and p=0.0003), number of recurrence sites (p=0.001 and p=0.0005), treatment at recurrence (p=0.044 and 0.043) and wb-MTV (p=0.023 and 0.021) but not with wb-TLG. RD, time to recurrence and number of recurrence sites, but not wb-MTV, were independent prognostic variables for post-relapse survival, and time to recurrence and number of recurrence sites, but not wb-MTV, were independent prognostic factors for overall survival. Conclusion: Volume-based parameters of PET/CT are not independent predictors of clinical outcome in potentially platinum-responsive recurrent ovarian cancer.
Databáze:	MEDLINE
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