Dual role of inositol-requiring enzyme 1α (IRE-1α) in Cd-induced apoptosis in human renal tubular epithelial cells: Endoplasmic reticulum stress and STAT3 signaling activation.
Autor: | Chou X; Shanghai Pulmonary Hospital Affiliated Tongji University, 507 Zhengmin Road, Shanghai, 200433, China; School of Public Health, Fudan University, 130 Dong'An Road, Shanghai, 200032, China., Ma K; Shanghai Pulmonary Hospital Affiliated Tongji University, 507 Zhengmin Road, Shanghai, 200433, China., Shen Y; Shanghai Pulmonary Hospital Affiliated Tongji University, 507 Zhengmin Road, Shanghai, 200433, China., Min Z; Shanghai Pulmonary Hospital Affiliated Tongji University, 507 Zhengmin Road, Shanghai, 200433, China., Wu Q; School of Public Health, Fudan University, 130 Dong'An Road, Shanghai, 200032, China. Electronic address: qingwu@fudan.edu.cn., Sun D; Shanghai Pulmonary Hospital Affiliated Tongji University, 507 Zhengmin Road, Shanghai, 200433, China. Electronic address: daoyun_sun@163.com. |
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Jazyk: | angličtina |
Zdroj: | Toxicology [Toxicology] 2021 May 30; Vol. 456, pp. 152769. Date of Electronic Publication: 2021 Apr 01. |
DOI: | 10.1016/j.tox.2021.152769 |
Abstrakt: | Cadmium (Cd) is a nephrotoxicant that primarily damages renal proximal tubular cells. Endoplasmic reticulum (ER) stress is mechanistically linked to Cd-induced renal injury. Inositol-requiring enzyme 1 (IRE-1α) is the most conserved ER stress transducer protein, which has both kinase and endonuclease activities. This study aimed to investigate whether the two enzymatic activities of IRE-1α have different effects in its regulation of Cd-induced apoptosis. Human proximal tubular (HK-2) cells were treated with 20 μM CdCl (Copyright © 2021. Published by Elsevier B.V.) |
Databáze: | MEDLINE |
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