T-wave peak-end interval and ratio of T-wave peak-end and QT intervals: novel arrhythmogenic and survival markers for dogs with myxomatous mitral valve disease.

Autor: Vila BCP; Laboratory of Comparative Cardiology, Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, 80035-050, Brazil. Electronic address: beatriz.pato@gmail.com., Camacho AA; Department of Veterinary Clinic and Surgery, São Paulo State University, Jaboticabal, SP, 14884-900, Brazil., Sousa MG; Laboratory of Comparative Cardiology, Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, 80035-050, Brazil.
Jazyk: angličtina
Zdroj: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology [J Vet Cardiol] 2021 Jun; Vol. 35, pp. 25-41. Date of Electronic Publication: 2021 Feb 27.
DOI: 10.1016/j.jvc.2021.02.004
Abstrakt: Introduction/objectives: In the past few years, novel markers such as the interval between the peak and the end of T-wave (Tpte) and Tpte/QT ratio have been shown to have high sensitivity for ventricular arrhythmias and mortality. We analyzed these and other parameters of ventricular repolarization, such as QT interval, QT interval corrected for heart rate (QTc), and QT dispersion (QTd) in dogs with myxomatous mitral valve disease (MMVD). Additionally, we investigated their relationship with the progression of the disease, echocardiographic parameters, and ventricular arrhythmias and assessed their prognostic value with development of clinical signs or mortality as the final outcome.
Animals, Materials and Methods: Epidemiological, clinical, echocardiographic, and electrocardiographic data were obtained from 236 dogs with MMVD and 15 healthy dogs. Prognostic and survival information was also recorded for the MMVD group. All ventricular repolarization indices were measured in 10 lead electrocardiographic recordings.
Results: With the exception of the QT interval, most repolarization markers increased along with the frequency of arrhythmias and with the progression of MMVD. The parameters that best identified ventricular arrhythmias (AUC > 0.7) were Tpte (aVR, rV2, average rV2-V10, average rV2-V4) and Tpte/QT (II, aVR, rV2). In survival analysis, statistically significant markers with the highest differences in median survival were Tpte (maximum of any lead, maximum rV2-V10), QTc aVR, and Tpte rV2.
Conclusion: Tpte and Tpte/QT are good non-invasive markers for clinical risk stratification in dogs with MMVD.
Competing Interests: Conflicts of interest statement The authors do not have any conflicts of interest to disclose.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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