Development, validation, and comparison of a nomogram based on radiologic findings for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: An international multicenter study.

Autor:	Kim HS; Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea., Song W; Department of Statistics, Seoul National University College of Natural Sciences, Seoul, South Korea., Choo W; Department of Statistics, Seoul National University College of Natural Sciences, Seoul, South Korea., Lee S; Center for Precision Medicine, Seoul National University Hospital, Seoul, South Korea., Han Y; Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea., Bassi C; Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy., Salvia R; Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy., Marchegiani G; Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy., Wolfgang CL; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., He J; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Blair AB; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kluger MD; Department of Surgery, Division of Gastrointestinal and Endocrine Surgery, College of Physicians and Surgeon, Columbia University, New York, NY, USA., Su GH; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Kim SC; Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea., Song KB; Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea., Yamamoto M; Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan., Hatori T; Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.; Department of Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan., Yang CY; Department of Surgery, National Taiwan University Hospital and National Taiwan Hospital, Taipei, Taiwan., Yamaue H; Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan., Hirono S; Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan., Satoi S; Department of Surgery, Kansai Medical University, Osaka, Japan., Fujii T; Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan., Hirano S; Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Hokkaido, Japan., Lou W; Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China., Hashimoto Y; Department of Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; Department of Surgery, Hiroshima Memorial Hospital, Hiroshima, Japan., Shimizu Y; Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan., Del Chiaro M; Pancreatic Surgery Unit, Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute at Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.; Department of Surgery, University of Colorado Anschutz Medical Campus, Denver, CO, USA., Valente R; Pancreatic Surgery Unit, Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute at Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.; Digestive and Liver Disease Unit, Sapienza University of Rome, Rome, Italy., Lohr M; Department for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.; Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden., Choi DW; Department of Surgery, Sungkyunkwan University School of Medicine, Seoul, South Korea., Choi SH; Department of Surgery, Sungkyunkwan University School of Medicine, Seoul, South Korea., Heo JS; Department of Surgery, Sungkyunkwan University School of Medicine, Seoul, South Korea., Motoi F; Department of Surgery, Tohoku University, Tohoku, Japan., Matsumoto I; Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Surgery, Kindai University Faculty of Medicine, Osaka, Japan., Lee WJ; Pancreaticobiliary Cancer Clinic, Yonsei Cancer Center, Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea., Kang CM; Pancreaticobiliary Cancer Clinic, Yonsei Cancer Center, Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea., Shyr YM; Department of Surgery, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan., Wang SE; Department of Surgery, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan., Han HS; Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, South Korea., Yoon YS; Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, South Korea., Besselink MG; Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., van Huijgevoort NCM; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Sho M; Department of Surgery, Nara Medical University, Nara, Japan., Nagano H; Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.; Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University, Yamaguchi, Japan., Kim SG; Department of Surgery, Kyungpook National University, Daegu, South Korea., Honda G; Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan., Yang Y; Department of General Surgery, Peking University First Hospital, Beijing, China., Yu HC; Department of Surgery, Jeonbuk National University Medical School, Jeonju, South Korea., Yang JD; Department of Surgery, Jeonbuk National University Medical School, Jeonju, South Korea., Chung JC; Department of Surgery, Soonchunhyang University, Asan, South Korea., Nagakawa Y; Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan., Seo HI; Department of Surgery, Pusan National University, Pusan, South Korea., Lee S; Department of Mathematics and Statistics, Sejong University, Seoul, South Korea., Kim H; Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea., Kwon W; Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea., Park T; Department of Statistics, Seoul National University College of Natural Sciences, Seoul, South Korea., Jang JY; Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Jazyk:	angličtina
Zdroj:	Journal of hepato-biliary-pancreatic sciences [J Hepatobiliary Pancreat Sci] 2023 Jan; Vol. 30 (1), pp. 133-143. Date of Electronic Publication: 2021 Apr 20.
DOI:	10.1002/jhbp.962
Abstrakt:	Background: Although we previously proposed a nomogram to predict malignancy in intraductal papillary mucinous neoplasms (IPMN) and validated it in an external cohort, its application is challenging without data on tumor markers. Moreover, existing nomograms have not been compared. This study aimed to develop a nomogram based on radiologic findings and to compare its performance with previously proposed American and Korean/Japanese nomograms. Methods: We recruited 3708 patients who underwent surgical resection at 31 tertiary institutions in eight countries, and patients with main pancreatic duct >10 mm were excluded. To construct the nomogram, 2606 patients were randomly allocated 1:1 into training and internal validation sets, and area under the receiver operating characteristics curve (AUC) was calculated using 10-fold cross validation by exhaustive search. This nomogram was then validated and compared to the American and Korean/Japanese nomograms using 1102 patients. Results: Among the 2606 patients, 90 had main-duct type, 900 had branch-duct type, and 1616 had mixed-type IPMN. Pathologic results revealed 1628 low-grade dysplasia, 476 high-grade dysplasia, and 502 invasive carcinoma. Location, cyst size, duct dilatation, and mural nodule were selected to construct the nomogram. AUC of this nomogram was higher than the American nomogram (0.691 vs 0.664, P = .014) and comparable with the Korean/Japanese nomogram (0.659 vs 0.653, P = .255). Conclusions: A novel nomogram based on radiologic findings of IPMN is competitive for predicting risk of malignancy. This nomogram would be clinically helpful in circumstances where tumor markers are not available. The nomogram is freely available at http://statgen.snu.ac.kr/software/nomogramIPMN. (© 2021 Japanese Society of Hepato-Biliary-Pancreatic Surgery.)
Databáze:	MEDLINE
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