Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus.

Autor:	Jang Y; Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea., Heo JY; Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea., Lee MJ; Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea., Zhu J; Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea., Seo C; Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea., Go DH; Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea., Yoon SK; Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Department of Medical Science, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea., Yukari D; Frontier Science Research Center, University of Miyazaki, Miyazaki 889-1692, Japan., Oike Y; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan., Sohn JW; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea., Shong M; Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Korea., Kweon GR; Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 35015, Korea.; Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea.
Jazyk:	angličtina
Zdroj:	International journal of molecular sciences [Int J Mol Sci] 2021 Mar 26; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 26.
DOI:	10.3390/ijms22073443
Abstrakt:	The hypothalamic regulation of appetite governs whole-body energy balance. Satiety is regulated by endocrine factors including leptin, and impaired leptin signaling is associated with obesity. Despite the anorectic effect of leptin through the regulation of the hypothalamic feeding circuit, a distinct downstream mediator of leptin signaling in neuron remains unclear. Angiopoietin-like growth factor (AGF) is a peripheral activator of energy expenditure and antagonizes obesity. However, the regulation of AGF expression in brain and localization to mediate anorectic signaling is unknown. Here, we demonstrated that AGF is expressed in proopiomelanocortin (POMC)-expressing neurons located in the arcuate nucleus (ARC) of the hypothalamus. Unlike other brain regions, hypothalamic AGF expression is stimulated by leptin-induced signal transducers and activators of transcription 3 (STAT3) phosphorylation. In addition, leptin treatment to hypothalamic N1 cells significantly enhanced the promoter activity of AGF. This induction was abolished by the pretreatment of ruxolitinib, a leptin signaling inhibitor. These results indicate that hypothalamic AGF expression is induced by leptin and colocalized to POMC neurons.
Databáze:	MEDLINE
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