Expansion of CD4 T Lymphocytes Expressing Interleukin 17 and Tumor Necrosis Factor in Patients with Major Depressive Disorder.

Autor: Alvarez-Mon MA; Department of Psychiatry and Medical Psychology, University Clinic of Navarra, Avda. Pío XII, 36, 31008 Pamplona, Spain.; Department of Medicine and Medical Specialities, University of Alcala, 28871 Alcala de Henares, Spain.; Department of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain., Gómez-Lahoz AM; Department of Medicine and Medical Specialities, University of Alcala, 28871 Alcala de Henares, Spain., Orozco A; Department of Psychiatry, University Hospital 'Principe de Asturias', 28805 Alcala de Henares, Spain., Lahera G; Department of Medicine and Medical Specialities, University of Alcala, 28871 Alcala de Henares, Spain.; Department of Psychiatry, University Hospital 'Principe de Asturias', 28805 Alcala de Henares, Spain.; CIBERSAM (Biomedical Research Networking Centre in Mental Health), 22807 Madrid, Spain., Diaz D; Department of Medicine and Medical Specialities, University of Alcala, 28871 Alcala de Henares, Spain., Ortega MA; Department of Medicine and Medical Specialities, University of Alcala, 28871 Alcala de Henares, Spain.; Institute Ramon y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain., Albillos A; Department of Medicine and Medical Specialities, University of Alcala, 28871 Alcala de Henares, Spain.; Institute Ramon y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain.; Department of Gastroenterology, University Hospital Ramon y Cajal, 28034 Madrid, Spain.; Biomedical Institute for Liver and Gut Diseases (CIBEREHD), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain., Quintero J; Department of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain.; Department of Legal and Psychiatry, Complutense University, 28040 Madrid, Spain., Aubá E; Department of Psychiatry and Medical Psychology, University Clinic of Navarra, Avda. Pío XII, 36, 31008 Pamplona, Spain., Monserrat J; Department of Medicine and Medical Specialities, University of Alcala, 28871 Alcala de Henares, Spain., Alvarez-Mon M; Department of Medicine and Medical Specialities, University of Alcala, 28871 Alcala de Henares, Spain.; Institute Ramon y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain.; Biomedical Institute for Liver and Gut Diseases (CIBEREHD), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain.; Service of Internal Medicine and Rheumatology, Autoimmune Diseases University Hospital 'Principe de Asturias', 28805 Alcala de Henares, Spain.
Jazyk: angličtina
Zdroj: Journal of personalized medicine [J Pers Med] 2021 Mar 19; Vol. 11 (3). Date of Electronic Publication: 2021 Mar 19.
DOI: 10.3390/jpm11030220
Abstrakt: Background: We have investigated the distribution of the Th1, Th2 and Th17 subsets in circulating CD4 + T lymphocytes and their naïve (T N ), effector (T E ), central (T CM ) and effector memory (T EM ) activation/differentiation stages in patients with major depressive disorder (MDD).
Methods: Thirty MDD patients and 30 healthy controls were studied. The counts of circulating CD4 + T lymphocytes and their distribution on the T N , T E , T CM and T EM activation/differentiation stages were analyzed by polychromatic flow cytometry. The intracytoplasmic interferon gamma (IFNγ), interleukin (IL)-4, IL-17A and tumor necrosis factor alpha (TNF-alpha) and membrane CD28 expression were also measured. The serum IFNγ, IL-4, Il-17A and TNF-alpha were measured by Luminex, respectively.
Results: MDD patients had normal counts of CD4 + T lymphocytes and of their T N , T CM and T EM subsets but increased number and percentage of T E CD4 + subset. CD4 + T lymphocytes had significantly enhanced percentage of cells that express IL-17 and TNF-alpha explained by the expansions found in the T N , T CM and, T EM and T CM , T EM and T E activation/differentiation stages, respectively. A selective increase in the percentages of T CM and T EM expressing IFNγ was also observed. We found a significant correlation between the percentages of CD4 + T lymphocytes expressing IFNγ and TNF-alpha in these patients. MDD patients showed increased serum levels of IL-17 and TNF-alpha, but normal IFNγ and IL-4 concentration.
Limitations: the cross-sectional nature of the study could be considered a limitation.
Conclusions: MDD patients have abnormal circulating CD4 + T lymphocytes with expansion of the IL-17 and TNF-alpha expressing cells as well as increased levels of circulating IL-17 and TNF-alpha.
Databáze: MEDLINE
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