Plasma Amyloid-Beta Levels in a Pre-Symptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross-Sectional and Longitudinal Investigation.

Autor: Chatterjee P; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW 2109, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia., Tegg M; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia., Pedrini S; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia., Fagan AM; Department of Neurology, Washington University, St. Louis, MO 63130, USA.; Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63130, USA., Xiong C; Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63130, USA.; Division of Biostatistics, Washington University, St. Louis, MO 63130, USA., Singh AK; Macquarie Business School, Macquarie University, North Ryde, NSW 2109, Australia., Taddei K; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.; Australian Alzheimer's Research Foundation, Nedlands, WA 6009, Australia., Gardener S; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia., Masters CL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3052, Australia., Schofield PR; Neuroscience Research Australia, Sydney, NSW 2031, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Multhaup G; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada., Benzinger TLS; Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63130, USA.; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Morris JC; Department of Neurology, Washington University, St. Louis, MO 63130, USA.; Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63130, USA., Bateman RJ; Department of Neurology, Washington University, St. Louis, MO 63130, USA.; Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63130, USA., Greenberg SM; Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, MA 02114, USA., van Buchem MA; Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Stoops E; ADx NeuroSciences, 9052 Gent, Belgium., Vanderstichele H; Biomarkable, 9000 Gent, Belgium., Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam University Medical Centers, 1007 MB Amsterdam, The Netherlands., Hankey GJ; Faculty of Health and Medical Sciences, Medical School, The University of Western Australia, Crawley, WA 6009, Australia., Wermer MJH; Department of Neurology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Sohrabi HR; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW 2109, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.; Australian Alzheimer's Research Foundation, Nedlands, WA 6009, Australia.; Centre for Healthy Ageing, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, WA 6150, Australia.; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA 6009, Australia., Martins RN; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW 2109, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.; Australian Alzheimer's Research Foundation, Nedlands, WA 6009, Australia.; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA 6009, Australia.; The KaRa Institute of Neurological Disease, Macquarie Park, NSW 2113, Australia., The Dominantly Inherited Alzheimer Network
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 13; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 13.
DOI: 10.3390/ijms22062931
Abstrakt: Plasma amyloid-beta (Aβ) has long been investigated as a blood biomarker candidate for Cerebral Amyloid Angiopathy (CAA), however previous findings have been inconsistent which could be attributed to the use of less sensitive assays. This study investigates plasma Aβ alterations between pre-symptomatic Dutch-type hereditary CAA (D-CAA) mutation-carriers (MC) and non-carriers (NC) using two Aβ measurement platforms. Seventeen pre-symptomatic members of a D-CAA pedigree were assembled and followed up 3-4 years later (NC = 8; MC = 9). Plasma Aβ1-40 and Aβ1-42 were cross-sectionally and longitudinally analysed at baseline (T1) and follow-up (T2) and were found to be lower in MCs compared to NCs, cross-sectionally after adjusting for covariates, at both T1(Aβ1-40: p = 0.001; Aβ1-42: p = 0.0004) and T2 (Aβ1-40: p = 0.001; Aβ1-42: p = 0.016) employing the Single Molecule Array (Simoa) platform, however no significant differences were observed using the xMAP platform. Further, pairwise longitudinal analyses of plasma Aβ1-40 revealed decreased levels in MCs using data from the Simoa platform ( p = 0.041) and pairwise longitudinal analyses of plasma Aβ1-42 revealed decreased levels in MCs using data from the xMAP platform ( p = 0.041). Findings from the Simoa platform suggest that plasma Aβ may add value to a panel of biomarkers for the diagnosis of pre-symptomatic CAA, however, further validation studies in larger sample sets are required.
Databáze: MEDLINE