Exhaled Breath Reflects Prolonged Exercise and Statin Use during a Field Campaign.

Autor: Henderson B; Department of Molecular and Laser Physics, Institute for Molecules and Materials, Radboud University, 6525 XZ Nijmegen, The Netherlands., Lopes Batista G; Department of Molecular and Laser Physics, Institute for Molecules and Materials, Radboud University, 6525 XZ Nijmegen, The Netherlands., Bertinetto CG; Department of Analytical Chemistry and Chemometrics, Institute for Molecules and Materials, Radboud University, 6525 XZ Nijmegen, The Netherlands., Meurs J; Department of Molecular and Laser Physics, Institute for Molecules and Materials, Radboud University, 6525 XZ Nijmegen, The Netherlands., Materić D; Department of Molecular and Laser Physics, Institute for Molecules and Materials, Radboud University, 6525 XZ Nijmegen, The Netherlands.; Institute for Marine and Atmospheric Research, Utrecht University, 3584 CC Utrecht, The Netherlands., Bongers CCWG; Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 XZ Nijmegen, The Netherlands., Allard NAE; Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 XZ Nijmegen, The Netherlands., Eijsvogels TMH; Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 XZ Nijmegen, The Netherlands., Holzinger R; Institute for Marine and Atmospheric Research, Utrecht University, 3584 CC Utrecht, The Netherlands., Harren FJM; Department of Molecular and Laser Physics, Institute for Molecules and Materials, Radboud University, 6525 XZ Nijmegen, The Netherlands., Jansen JJ; Department of Analytical Chemistry and Chemometrics, Institute for Molecules and Materials, Radboud University, 6525 XZ Nijmegen, The Netherlands., Hopman MTE; Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 XZ Nijmegen, The Netherlands., Cristescu SM; Department of Molecular and Laser Physics, Institute for Molecules and Materials, Radboud University, 6525 XZ Nijmegen, The Netherlands.
Jazyk: angličtina
Zdroj: Metabolites [Metabolites] 2021 Mar 24; Vol. 11 (4). Date of Electronic Publication: 2021 Mar 24.
DOI: 10.3390/metabo11040192
Abstrakt: Volatile organic compounds (VOCs) in exhaled breath provide insights into various metabolic processes and can be used to monitor physiological response to exercise and medication. We integrated and validated in situ a sampling and analysis protocol using proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) for exhaled breath research. The approach was demonstrated on a participant cohort comprising users of the cholesterol-lowering drug statins and non-statin users during a field campaign of three days of prolonged and repeated exercise, with no restrictions on food or drink consumption. The effect of prolonged exercise was reflected in the exhaled breath of participants, and relevant VOCs were identified. Most of the VOCs, such as acetone, showed an increase in concentration after the first day of walking and subsequent decrease towards baseline levels prior to walking on the second day. A cluster of short-chain fatty acids including acetic acid, butanoic acid, and propionic acid were identified in exhaled breath as potential indicators of gut microbiota activity relating to exercise and drug use. We have provided novel information regarding the use of breathomics for non-invasive monitoring of changes in human metabolism and especially for the gut microbiome activity in relation to exercise and the use of medication, such as statins.
Databáze: MEDLINE
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