Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on 18 F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression.

Autor: Mittlmeier LM; Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany., Ledderose ST; Institute of Pathology, LMU Munich, 81377 Munich, Germany., Schott M; Department of Urology, University Hospital, LMU Munich, 81377 Munich, Germany., Brendel M; Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany., Beyer L; Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany., Theurich S; Department of Medicine III, University Hospital, LMU Munich, 81377 Munich, Germany., Mayr D; Institute of Pathology, LMU Munich, 81377 Munich, Germany., Walz C; Institute of Pathology, LMU Munich, 81377 Munich, Germany., Kunz WG; Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany., Ricke J; Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany., Bartenstein P; Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany., Ilhan H; Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany., Staehler M; Department of Urology, University Hospital, LMU Munich, 81377 Munich, Germany., Unterrainer M; Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2021 Mar 03; Vol. 11 (3). Date of Electronic Publication: 2021 Mar 03.
DOI: 10.3390/diagnostics11030423
Abstrakt: We present a 71-year-old female patient who underwent 18 F-PSMA-1007 PET/CT for suspected metastatic renal cell carcinoma (RCC), as RCC also shows high PSMA-expression in tumor neovascularization. 18 F-PSMA-1007 PET/CT showed a high PSMA-avidity in the renal tumor, enlarged intra-abdominal and mediastinal lymph nodes. Moreover, PSMA-positive pleural, pulmonal and osseous lesions were found. However, histopathology revealed an immature plasma cell myeloma with an endothelial PSMA-expression of the neovasculature. This case illustrates the increased PSMA-avidity in multiple myeloma and highlights PSMA as a potential theragnostic target in multiple myeloma. For clinical routine, lymphatic diseases such as extramedullary myeloma should be considered as differential diagnosis in PSMA-avid renal masses on PET/CT.
Databáze: MEDLINE
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