| Autor: |
Hanna-Sawires RG; Department of Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Schiphuis JH; Department of Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Wuhrer M; Center of Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Vasen HFA; Department of Gastroenterology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van Leerdam ME; Department of Gastroenterology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bonsing BA; Department of Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Mesker WE; Department of Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van der Burgt YEM; Center of Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Tollenaar RAEM; Department of Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. |
| Abstrakt: |
Pancreatic ductal adenocarcinoma (PDAC) is known as a highly aggressive malignant disease. Prognosis for patients is notoriously poor, despite improvements in surgical techniques and new (neo)adjuvant chemotherapy regimens. Early detection of PDAC may increase the overall survival. It is furthermore foreseen that precision medicine will provide improved prognostic stratification and prediction of therapeutic response. In this review, omics-based discovery efforts are presented that aim for novel diagnostic and prognostic biomarkers of PDAC. For this purpose, we systematically evaluated the literature published between 1999 and 2020 with a focus on protein- and protein-glycosylation biomarkers in pancreatic cancer patients. Besides genomic and transcriptomic approaches, mass spectrometry (MS)-based proteomics and glycomics of blood- and tissue-derived samples from PDAC patients have yielded new candidates with biomarker potential. However, for reasons discussed in this review, the validation and clinical translation of these candidate markers has not been successful. Consequently, there has been a change of mindset from initial efforts to identify new unimarkers into the current hypothesis that a combination of biomarkers better suits a diagnostic or prognostic panel. With continuing development of current research methods and available techniques combined with careful study designs, new biomarkers could contribute to improved detection, prognosis, and prediction of pancreatic cancer. |
