Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration.

Autor: Gómez JG; Otolaryngology, Medical Center Foltra, 15886 Teo, Spain., Devesa J; Scientific Direction, Medical Center Foltra, 15886 Teo, Spain.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 11; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 11.
DOI: 10.3390/ijms22062829
Abstrakt: Growth hormone (GH) plays an important role in auditory development during the embryonic stage. Exogenous agents such as sound, noise, drugs or trauma, can induce the release of this hormone to perform a protective function and stimulate other mediators that protect the auditory pathway. In addition, GH deficiency conditions hearing loss or central auditory processing disorders. There are promising animal studies that reflect a possible regenerative role when exogenous GH is used in hearing impairments, demonstrated in in vivo and in vitro studies, and also, even a few studies show beneficial effects in humans presented and substantiated in the main text, although they should not exaggerate the main conclusions.
Databáze: MEDLINE