The development of and recovery from form-deprivation myopia in infant rhesus monkeys reared under reduced ambient lighting.

Autor: She Z; College of Optometry, University of Houston, Houston, TX, United States., Hung LF; College of Optometry, University of Houston, Houston, TX, United States; Brien Holden Vision Institute, Sydney, NSW, Australia., Arumugam B; College of Optometry, University of Houston, Houston, TX, United States; Former employee of University of Houston, Houston, TX, United States., Beach KM; College of Optometry, University of Houston, Houston, TX, United States., Smith EL 3rd; College of Optometry, University of Houston, Houston, TX, United States; Brien Holden Vision Institute, Sydney, NSW, Australia. Electronic address: esmith@uh.edu.
Jazyk: angličtina
Zdroj: Vision research [Vision Res] 2021 Jun; Vol. 183, pp. 106-117. Date of Electronic Publication: 2021 Mar 30.
DOI: 10.1016/j.visres.2021.02.004
Abstrakt: Although reduced ambient lighting ("dim" light) can cause myopia in emmetropizing chicks, it does not necessarily lead to myopic changes in emmetropizing rhesus monkeys. Because myopia is rarely spontaneous, a question remained whether dim light would hasten the progression of visually induced myopia. To determine the effects of dim light on the development of and recovery from form-deprivation myopia (FDM), seven 3-week-old infant rhesus monkeys were reared under dim light (mean ± SD = 55 ± 9 lx) with monocular diffuser spectacles until ~154 days of age, then maintained in dim light with unrestricted vision until ~337 days of age to allow for recovery. Refractive errors, corneal powers, ocular axial dimensions and sub-foveal choroidal thicknesses were measured longitudinally and compared to those obtained from form-deprived monkeys reared under typical laboratory lighting (504 ± 168 lx). Five of the seven subjects developed FDMs that were similar to those observed among their normal-light-reared counterparts. The average degree of form-deprivation-induced myopic anisometropia did not differ significantly between dim-light subjects (-3.88 ± 3.26D) and normal-light subjects (-4.45 ± 3.75D). However, three of the five dim-light subjects that developed obvious FDM failed to exhibit any signs of recovery and the two monkeys that were isometropic at the end of the treatment period manifest abnormal refractive errors during the recovery period. All refractive changes were associated with alterations in vitreous chamber elongation rates. It appears that dim light is not a strong myopiagenic stimulus by itself, but it can impair the optical regulation of refractive development in primates.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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