Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRI.

Autor:	Zandstra TE; Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands., Jongbloed MRM; Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands., Widya RL; Department of Radiology, Leiden University Medical Center, Leiden, Netherlands., Ten Harkel ADJ; Department of Paediatrics, Leiden University Medical Center, Leiden, Netherlands., Holman ER; Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands., Mertens BJA; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands., Vliegen HW; Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands., Egorova AD; Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands., Schalij MJ; Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands., Kiès P; Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2021 Mar 16; Vol. 8, pp. 644193. Date of Electronic Publication: 2021 Mar 16 (Print Publication: 2021).
DOI:	10.3389/fcvm.2021.644193
Abstrakt:	Background: Inherent to its geometry, echocardiographic imaging of the systemic right ventricle (RV) is challenging. Therefore, echocardiographic assessment of systemic RV function may not always be feasible and/or reproducible in daily practice. Here, we aim to validate the usefulness of a comprehensive range of 32 echocardiographic measurements of systemic RV function in a longitudinal cohort by serial assessment of their correlations with cardiac magnetic resonance (CMR)-derived systemic RV ejection fraction (RVEF). Methods: A single-center, retrospective cohort study was performed. Adult patients with a systemic RV who underwent a combination of both CMR and echocardiography at two different points in time were included. Off-line analysis of echocardiographic images was blinded to off-line CMR analysis and vice versa. In half of the echocardiograms, measurements were repeated by a second observer blinded to the results of the first. Correlations between echocardiographic and CMR measures were assessed with Pearson's correlation coefficient and interobserver agreement was quantified with intraclass correlation coefficients (ICC). Results: Fourteen patients were included, of which 4 had congenitally corrected transposition of the great arteries (ccTGA) and 10 patients had TGA late after an atrial switch operation. Eight patients (57%) were female. There was a mean of 8 years between the first and second imaging assessment. Only global systemic RV function, fractional area change (FAC), and global longitudinal strain (GLS) were consistently, i.e., at both time points, correlated with CMR-RVEF (global RV function: r = -0.77/ r = -0.63; FAC: r = 0.79/ r = 0.67; GLS: r = -0.73/ r = -0.70, all p -values < 0.05). The ICC of GLS (0.82 at t = 1, p = 0.006, 0.77 at t = 2, p = 0.024) was higher than the ICC of FAC (0.35 at t = 1, p = 0.196, 0.70 at t = 2, p = 0.051) at both time points. Conclusion: GLS appears to be the most robust echocardiographic measurement of systemic RV function with good correlation with CMR-RVEF and reproducibility. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Zandstra, Jongbloed, Widya, ten Harkel, Holman, Mertens, Vliegen, Egorova, Schalij and Kiès.)
Databáze:	MEDLINE
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