Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation.

Autor:	de Oliveira LG; Neuroimmune Interactions Laboratory, Immunology Department - Institute of Biomedical Sciences (ICB) IV, University of São Paulo (USP), São Paulo, Brazil.; Neuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo (USP), São Paulo, Brazil., Angelo YS; Neuroimmune Interactions Laboratory, Immunology Department - Institute of Biomedical Sciences (ICB) IV, University of São Paulo (USP), São Paulo, Brazil.; Neuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo (USP), São Paulo, Brazil., Iglesias AH; Loyola University Medical Center, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, United States., Peron JPS; Neuroimmune Interactions Laboratory, Immunology Department - Institute of Biomedical Sciences (ICB) IV, University of São Paulo (USP), São Paulo, Brazil.; Neuroimmunology of Arboviruses Laboratory, Scientific Platform Pasteur-USP, University of São Paulo (USP), São Paulo, Brazil.; Loyola University Medical Center, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2021 Mar 16; Vol. 12, pp. 624919. Date of Electronic Publication: 2021 Mar 16 (Print Publication: 2021).
DOI:	10.3389/fimmu.2021.624919
Abstrakt:	Neuroinflammatory and neurodegenerative diseases are a major public health problem worldwide, especially with the increase of life-expectancy observed during the last decades. For many of these diseases, we still lack a full understanding of their etiology and pathophysiology. Nonetheless their association with mitochondrial dysfunction highlights this organelle as an important player during CNS homeostasis and disease. Markers of Parkinson (PD) and Alzheimer (AD) diseases are able to induce innate immune pathways induced by alterations in mitochondrial Ca 2+ homeostasis leading to neuroinflammation. Additionally, exacerbated type I IFN responses triggered by mitochondrial DNA (mtDNA), failures in mitophagy, ER-mitochondria communication and mtROS production promote neurodegeneration. On the other hand, regulation of mitochondrial dynamics is essential for CNS health maintenance and leading to the induction of IL-10 and reduction of TNF-α secretion, increased cell viability and diminished cell injury in addition to reduced oxidative stress. Thus, although previously solely seen as power suppliers to organelles and molecular processes, it is now well established that mitochondria have many other important roles, including during immune responses. Here, we discuss the importance of these mitochondrial dynamics during neuroinflammation, and how they correlate either with the amelioration or worsening of CNS disease. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 de Oliveira, Angelo, Iglesias and Peron.)
Databáze:	MEDLINE
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