Concordance of a High Polygenic Score Among Relatives: Implications for Genetic Counseling and Cascade Screening.

Autor: Reid NJ; Cardiovascular Disease Initiative and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (N.J.R., D.G.B., C.E.L., R.P., A.V.K.).; Harvard Medical School, Boston, MA (N.J.R., A.V.K.)., Brockman DG; Department of Medicine, Harvard Medical School, Center for Genomic Medicine and Division of Cardiology, Massachusetts General Hospital, Boston (D.G.B., C.E.L., R.P., A.V.K.).; Cardiovascular Disease Initiative and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (N.J.R., D.G.B., C.E.L., R.P., A.V.K.)., Elisabeth Leonard C; Department of Medicine, Harvard Medical School, Center for Genomic Medicine and Division of Cardiology, Massachusetts General Hospital, Boston (D.G.B., C.E.L., R.P., A.V.K.).; Cardiovascular Disease Initiative and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (N.J.R., D.G.B., C.E.L., R.P., A.V.K.)., Pelletier R; Department of Medicine, Harvard Medical School, Center for Genomic Medicine and Division of Cardiology, Massachusetts General Hospital, Boston (D.G.B., C.E.L., R.P., A.V.K.).; Cardiovascular Disease Initiative and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (N.J.R., D.G.B., C.E.L., R.P., A.V.K.)., Khera AV; Department of Medicine, Harvard Medical School, Center for Genomic Medicine and Division of Cardiology, Massachusetts General Hospital, Boston (D.G.B., C.E.L., R.P., A.V.K.).; Cardiovascular Disease Initiative and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (N.J.R., D.G.B., C.E.L., R.P., A.V.K.).; Harvard Medical School, Boston, MA (N.J.R., A.V.K.).
Jazyk: angličtina
Zdroj: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2021 Apr; Vol. 14 (2), pp. e003262. Date of Electronic Publication: 2021 Apr 02.
DOI: 10.1161/CIRCGEN.120.003262
Databáze: MEDLINE