COVID-19 Mortality and Case-Fatality Rates in Sergipe State, Northeast Brazil, From April to June 2020.

Autor:	Martins-Filho PR; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Brazil.; Graduate Program in Health Science, Federal University of Sergipe, Aracaju, Brazil., Araújo AAS; Graduate Program in Health Science, Federal University of Sergipe, Aracaju, Brazil., Góes MAO; Health Secretariat of Sergipe State, Aracaju, Brazil., de Souza MSF; Graduate Program in Health Science, Federal University of Sergipe, Aracaju, Brazil.; Health Secretariat of Sergipe State, Aracaju, Brazil., Quintans-Júnior LJ; Graduate Program in Health Science, Federal University of Sergipe, Aracaju, Brazil., Martins N; Faculty of Medicine, University of Porto, Porto, Portugal.; Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.; Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal., Santos VS; Graduate Program in Health Science, Federal University of Sergipe, Aracaju, Brazil.; Centre for Epidemiology and Public Health, Federal University of Alagoas, Arapiraca, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2021 Mar 09; Vol. 9, pp. 581618. Date of Electronic Publication: 2021 Mar 09 (Print Publication: 2021).
DOI:	10.3389/fpubh.2021.581618
Abstrakt:	Information on how coronavirus disease 2019 (COVID-19) mortality is related to population characteristics in low- and middle-income countries is still limited. We described the deaths from COVID-19 in Sergipe state, Northeast Brazil, from April 2 to June 27, 2020. For this purpose, we conducted a study composed of (i) a case series study of all deaths due to COVID-19 and (ii) a population-based study to verify the behavior of the mortality and case-fatality rates (CFR) related to COVID-19. Data from 605 deaths due to COVID-19 were used to describe the characteristics of individuals with the disease, as well as the differences in gender, age, and comorbidities. Additionally, population data were extracted to estimate the mortality and CFR by population stratum. We also performed an adjusted CFR analysis including a time lag of 14 days between the onset of symptoms and reporting deaths. Of the 605 patients included in this study, 321 (53.1%) were males and the median age was 67.0 years. Most patients ( n = 447, 73.9%) who died from COVID-19 had at least one pre-existing clinical condition. The mortality rate was 29.3 deaths per 100,000 inhabitants and the crude CRF was 2.6% (95% CI 2.4-2.8). CFR was higher in males (3.1%, 95% CI 2.8-3.4; p < 0.001) and people aged ≥60 years (14.2%, 95% CI 13.0-15.6; p = 0.042). About 25% of patients died during the first 24-h post-hospital admission. The adjusted CFR for a 14-day time lag was ~2-fold higher than the crude CFR over the study period. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer SG declared a shared affiliation with one of the authors, NM to the handling editor at time of review. (Copyright © 2021 Martins-Filho, Araújo, Góes, de Souza, Quintans-Júnior, Martins and Santos.)
Databáze:	MEDLINE
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