The Future of Blood Testing Is the Immunome.
| Autor: | Arnaout RA; Department of Pathology and Division of Clinical Informatics, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States.; Department of Pathology, Harvard Medical School, Boston, MA, United States., Prak ETL; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Schwab N; Department of Neurology and Institute of Translational Neurology, University of Muenster, Muenster, Germany., Rubelt F; Roche Sequencing Solutions, Pleasanton, CA, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in immunology [Front Immunol] 2021 Mar 15; Vol. 12, pp. 626793. Date of Electronic Publication: 2021 Mar 15 (Print Publication: 2021). |
| DOI: | 10.3389/fimmu.2021.626793 |
| Abstrakt: | It is increasingly clear that an extraordinarily diverse range of clinically important conditions-including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions, aging, and cancers-leave telltale signatures in the millions of V(D)J-rearranged antibody and T cell receptor [TR per the Human Genome Organization (HUGO) nomenclature but more commonly known as TCR] genes collectively expressed by a person's B cells (antibodies) and T cells. We refer to these as the immunome . Because of its diversity and complexity, the immunome provides singular opportunities for advancing personalized medicine by serving as the substrate for a highly multiplexed, near-universal blood test. Here we discuss some of these opportunities, the current state of immunome-based diagnostics, and highlight some of the challenges involved. We conclude with a call to clinicians, researchers, and others to join efforts with the Adaptive Immune Receptor Repertoire Community (AIRR-C) to realize the diagnostic potential of the immunome. Competing Interests: Author FR was employed by Roche Sequencing Solutions. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Arnaout, Prak, Schwab, Rubelt and the Adaptive Immune Receptor Repertoire Community.) |
| Databáze: | MEDLINE |
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