Associations between TGF- β 1 Levels and Markers of Hemolysis, Inflammation, and Tissue Remodeling in Pediatric Sickle Cell Patients.

Autor: Santiago RP; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40.296-710 Salvador, Brazil.; Universidade Federal da Bahia, 40.170-110 Salvador, Brazil., Carvalho MOS; Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, 40110-060 Salvador, Brazil., Figueiredo CVB; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40.296-710 Salvador, Brazil.; Universidade Federal da Bahia, 40.170-110 Salvador, Brazil., Fiuza LM; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40.296-710 Salvador, Brazil.; Universidade Federal da Bahia, 40.170-110 Salvador, Brazil., Oliveira RM; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40.296-710 Salvador, Brazil.; Universidade Federal da Bahia, 40.170-110 Salvador, Brazil., Yahouédéhou SCMA; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40.296-710 Salvador, Brazil.; Universidade Federal da Bahia, 40.170-110 Salvador, Brazil., Nascimento VML; Fundação de Hematologia e Hemoterapia do Estado da Bahia, 40286-240 Salvador, Brazil., Lyra IM; Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, 40110-060 Salvador, Brazil.; Fundação de Hematologia e Hemoterapia do Estado da Bahia, 40286-240 Salvador, Brazil., Araujo-Santos T; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40.296-710 Salvador, Brazil., Luz NF; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40.296-710 Salvador, Brazil., Aleluia MM; Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, 45.662-900 Ilhéus, Brazil., Guarda CC; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40.296-710 Salvador, Brazil.; Universidade Federal da Bahia, 40.170-110 Salvador, Brazil., Borges VM; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40.296-710 Salvador, Brazil., Goncalves MS; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40.296-710 Salvador, Brazil.; Universidade Federal da Bahia, 40.170-110 Salvador, Brazil.
Jazyk: angličtina
Zdroj: Mediators of inflammation [Mediators Inflamm] 2021 Mar 13; Vol. 2021, pp. 4651891. Date of Electronic Publication: 2021 Mar 13 (Print Publication: 2021).
DOI: 10.1155/2021/4651891
Abstrakt: Transforming growth factor beta (TGF- β ) is a cytokine with important involvement in biological processes related to the pathogenesis of sickle cell disease (SCD), including endothelial and vascular dysfunction, inflammation, and hematopoietic homeostasis. This study is aimed at investigating associations between levels of TGF- β 1 and classical laboratory biomarkers and inflammatory mediators, as well as the tissue inhibitor of metalloproteases-1 (TIMP-1) and matrix metalloproteinase-9 (MMP-9), in pediatric patients ( n = 123) with SCD in steady state: 84 with sickle cell anemia (HbSS) and 39 with hemoglobin SC disease (HbSC). A healthy control (HC) group of 59 individuals was also included. Hematological and biochemical analyses were carried out using electronic methods. TGF- β 1, TIMP-1, and MMP-9 plasma quantifications were performed by ELISA. TGF- β 1 plasma levels were higher in HbSS individuals than in HbSC and HC. In individuals with HbSS, TGF- β 1 levels were positively correlated with red blood cells, hemoglobin, hematocrit, platelets, and TIMP-1. In addition, HbSS individuals with TGF- β 1 levels above the median (≥72.29 ng/mL) also presented increased monocyte counts and decreased albumin levels. In patients with HbSC, TGF- β 1 levels were positively correlated with leukocytes, eosinophils, lymphocytes, monocytes, and platelets, as well as levels of TIMP-1, VLDL-C, triglycerides, heme, and AST. Additionally, HbSC individuals with TGF- β 1 levels above the median (≥47.80 ng/mL) presented increased leukocyte and platelet counts, as well as increased levels of triglycerides, VLDL-C, MMP-9, and TIMP-1, and decreased HDL-C. Our findings suggest that TGF- β 1 may play important roles in vascular remodeling, vasculopathy, angiogenesis, and inflammation in pediatric patients with SCD.
Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper.
(Copyright © 2021 Rayra P. Santiago et al.)
Databáze: MEDLINE
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