Congenital Hypothyroidism in Children - A Cross-Sectional Study in a Tertiary Centre in Malaysia.

Autor:	Anuar Zaini A; Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Feng Tung Y; Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Ahmad Bahuri NF; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Yazid Jalaludin M; Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Jazyk:	angličtina
Zdroj:	Journal of the ASEAN Federation of Endocrine Societies [J ASEAN Fed Endocr Soc] 2020; Vol. 35 (1), pp. 62-67. Date of Electronic Publication: 2020 Apr 21.
DOI:	10.15605/jafes.035.01.11
Abstrakt:	Introduction: The causes of congenital hypothyroidism (CHT) are thyroid dysgenesis (TD), dyshormonogenesis (TDH) or transient hypothyroidism (TH). Methodology: This is a cross-sectional study looking at data over a period of 16 years (2000-2016). Confirmed cases had thyroid scan at the age of 3-years-old and repeated TFT (after 6 weeks off medications). Relevant data was collected retrospectively. Results: Forty (60% female) children with CHT were included in the study. Thirty (75%) children presented with high cord TSH. Nine (23%) presented after 2 weeks of life. Majority were diagnosed with TDH (42.5%) with TD and TH of 40% and 17.5% respectively. Median cord TSH of children with TD was significantly higher compared to TDH and TH (p=0.028 and p=0.001 respectively). L-thyroxine doses were not significantly different between TD, TDH and TH at diagnosis or at 3 years. Conclusions: TDH is highly prevalent in our population. TD may present after 2 weeks of life. One in five children treated for CHT had TH. Differentiating TD, TDH and TH before initiating treatment remains a challenge in Malaysia. This study provides clinicians practical information needed to understand the possible aetiologies from a patient's clinical presentation, biochemical markers and treatment regime. Reassessing TH cases may be warranted to prevent unnecessary treatment. (© 2020 Journal of the ASEAN Federation of Endocrine Societies.)
Databáze:	MEDLINE
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